Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA

The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA–protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific n...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2021-08, Vol.86 (8), p.1025-1040
Main Author: Nikulin, Alexey D.
Format: Article
Language:English
Subjects:
Amino acids
Binding proteins
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Double-stranded RNA
Genetic translation
Life Sciences
Messenger RNA
Microbiology
Molecular structure
Nucleotides
Protein binding
Protein interaction
Protein structure
Proteins
Review
Citations: Items that this one cites
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Description
Summary:The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA–protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297921080125