Glycan Assembly Strategy: From Concept to Application

Glycans have been hot topics in recent years due to their exhibition of numerous biological activities. However, the heterogeneity of their natural source and the complexity of their chemical synthesis impede the progress in their biological research. Thus, the development of glycan assembly strateg...

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Bibliographic Details
Published in:Chemical record 2021-11, Vol.21 (11), p.3256-3277
Main Authors: Liu, Mingli, Qin, Xianjin, Ye, Xin‐Shan
Format: Article
Language:English
Subjects:
Assembly
automated glycan assembly
Biological research
carbohydrate
Carbohydrates
Chemical synthesis
Glycan
glycosylation
Heterogeneity
Polysaccharides
synthesis
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Summary:Glycans have been hot topics in recent years due to their exhibition of numerous biological activities. However, the heterogeneity of their natural source and the complexity of their chemical synthesis impede the progress in their biological research. Thus, the development of glycan assembly strategies to acquire plenty of structurally well‐defined glycans is an important issue in carbohydrate chemistry. In this review, the latest advances in glycan assembly strategies from concepts to their applications in carbohydrate synthesis, including chemical and enzymatic/chemo‐enzymatic approaches, as well as solution‐phase and solid‐phase/tag‐assisted synthesis, are summarized. Furthermore, the automated glycan assembly techniques are also outlined. The latest advances in glycan assembly strategies from concepts to their applications in carbohydrate synthesis, including chemical and enzymatic/chemo‐enzymatic approaches, as well as solution‐phase and solid‐phase/tag‐assisted synthesis, are summarized. Furthermore, the automated glycan assembly techniques are also outlined.
ISSN:1527-8999
1528-0691
DOI:10.1002/tcr.202100183