The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance

•The TyG index predicts type 2 diabetes (T2D) prevalence better than HOMA-IR.•The TyG index showed superior predictability for incidence of T2D than HOMA-IR.•The optimal value of the TyG index and HOMA-IR predicting T2D are low in East Asians. Insulin resistance is an independent risk factor for dev...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes research and clinical practice 2021-10, Vol.180, p.109042-109042, Article 109042
Main Authors: Park, Hye Min, Lee, Hye Sun, Lee, Yong-Jae, Lee, Jun-Hyuk
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Blood Glucose
Diabetes Mellitus, Type 2 - epidemiology
Glucose
HOMA-IR
Humans
Incidence
Insulin Resistance
Middle Aged
Prevalence
Triglycerides
TyG index
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The TyG index predicts type 2 diabetes (T2D) prevalence better than HOMA-IR.•The TyG index showed superior predictability for incidence of T2D than HOMA-IR.•The optimal value of the TyG index and HOMA-IR predicting T2D are low in East Asians. Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2021.109042