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Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease
The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear. A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of ,...
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| Published in: | Pharmacogenomics 2021-08, Vol.22 (13), p.821-831 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c343t-aa565234c0e215fdd23bbab50ad5b7b1dd437fbeeb31996fb6d5fabaf0491fcc3 |
| container_end_page | 831 |
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| container_title | Pharmacogenomics |
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| creator | Zhang, Weixia Jin, Yiwen Li, Juan Huang, Jingjing Chen, Hefeng |
| description | The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear.
A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of
,
,
,
,
,
,
and
were genotyped using direct sequencing in all subjects.
The mutation of
rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in
and rs62293298 in
were also confirmed to be associated with hyperuricemia.
Age, weight, creatinine clearance rate, diuretics and SNPs on
,
and
were all risk factors of hyperuricemia. |
| doi_str_mv | 10.2217/pgs-2021-0053 |
| format | article |
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A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of
,
,
,
,
,
,
and
were genotyped using direct sequencing in all subjects.
The mutation of
rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in
and rs62293298 in
were also confirmed to be associated with hyperuricemia.
Age, weight, creatinine clearance rate, diuretics and SNPs on
,
and
were all risk factors of hyperuricemia.</description><identifier>ISSN: 1462-2416</identifier><identifier>EISSN: 1744-8042</identifier><identifier>DOI: 10.2217/pgs-2021-0053</identifier><identifier>PMID: 34505535</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adult ; Aged ; Asians ; ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ; Case-Control Studies ; China - epidemiology ; Coronary Artery Disease - complications ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; coronary heart disease ; drug transporter gene ; Female ; Genetic Predisposition to Disease ; Genotype ; Glucose Transport Proteins, Facilitative - genetics ; Humans ; hyperuricemia ; Hyperuricemia - complications ; Hyperuricemia - epidemiology ; Hyperuricemia - genetics ; Male ; Middle Aged ; Mutation - genetics ; Neoplasm Proteins - genetics ; Organic Anion Transporters - genetics ; Organic Cation Transport Proteins - genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; SNP</subject><ispartof>Pharmacogenomics, 2021-08, Vol.22 (13), p.821-831</ispartof><rights>2021 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-aa565234c0e215fdd23bbab50ad5b7b1dd437fbeeb31996fb6d5fabaf0491fcc3</citedby><cites>FETCH-LOGICAL-c343t-aa565234c0e215fdd23bbab50ad5b7b1dd437fbeeb31996fb6d5fabaf0491fcc3</cites><orcidid>0000-0003-0522-9923 ; 0000-0002-0206-0766 ; 0000-0002-2049-8729 ; 0000-0002-8186-2045</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34505535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Weixia</creatorcontrib><creatorcontrib>Jin, Yiwen</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Huang, Jingjing</creatorcontrib><creatorcontrib>Chen, Hefeng</creatorcontrib><title>Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease</title><title>Pharmacogenomics</title><addtitle>Pharmacogenomics</addtitle><description>The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear.
A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of
,
,
,
,
,
,
and
were genotyped using direct sequencing in all subjects.
The mutation of
rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in
and rs62293298 in
were also confirmed to be associated with hyperuricemia.
Age, weight, creatinine clearance rate, diuretics and SNPs on
,
and
were all risk factors of hyperuricemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Asians</subject><subject>ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>coronary heart disease</subject><subject>drug transporter gene</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glucose Transport Proteins, Facilitative - genetics</subject><subject>Humans</subject><subject>hyperuricemia</subject><subject>Hyperuricemia - complications</subject><subject>Hyperuricemia - epidemiology</subject><subject>Hyperuricemia - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Neoplasm Proteins - genetics</subject><subject>Organic Anion Transporters - genetics</subject><subject>Organic Cation Transport Proteins - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>SNP</subject><issn>1462-2416</issn><issn>1744-8042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kDlPAzEQRi0EIlwlLXJJs-Bzly1RxCVFooHa8jEmhsS72F4h_j2OEuiovhnpzafRQ-ickivGaHc9vuWGEUYbQiTfQ0e0E6K5IYLt11m0rGGCtjN0nPM7qVgryCGacSGJlFweoY8778GWjAeP3yBCCRbr6HAc4u_qtS1DqkTEy-8R0pSChXXQOEQ8X4YIGfCoS4BYa75CWWI7pCHq9I11KlDDhQw6wyk68HqV4WyXJ-j1_u5l_tgsnh-e5reLxnLBS6O1bCXjwhJgVHrnGDdGG0m0k6Yz1DnBO28ADKd933rTOum10Z6Innpr-Qm63PaOaficIBe1DtnCaqUjDFNWTHa0Z4S3vKLNFrVpyDmBV2MK6_q6okRt_KrqV238qo3fyl_sqiezBvdH_wqtQL8F_FSmBNlWLRbUdqsXwVZh_5T_ACyQjNs</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Zhang, Weixia</creator><creator>Jin, Yiwen</creator><creator>Li, Juan</creator><creator>Huang, Jingjing</creator><creator>Chen, Hefeng</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0522-9923</orcidid><orcidid>https://orcid.org/0000-0002-0206-0766</orcidid><orcidid>https://orcid.org/0000-0002-2049-8729</orcidid><orcidid>https://orcid.org/0000-0002-8186-2045</orcidid></search><sort><creationdate>20210801</creationdate><title>Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease</title><author>Zhang, Weixia ; Jin, Yiwen ; Li, Juan ; Huang, Jingjing ; Chen, Hefeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-aa565234c0e215fdd23bbab50ad5b7b1dd437fbeeb31996fb6d5fabaf0491fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asians</topic><topic>ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>coronary heart disease</topic><topic>drug transporter gene</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glucose Transport Proteins, Facilitative - genetics</topic><topic>Humans</topic><topic>hyperuricemia</topic><topic>Hyperuricemia - complications</topic><topic>Hyperuricemia - epidemiology</topic><topic>Hyperuricemia - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Neoplasm Proteins - genetics</topic><topic>Organic Anion Transporters - genetics</topic><topic>Organic Cation Transport Proteins - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>SNP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Weixia</creatorcontrib><creatorcontrib>Jin, Yiwen</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Huang, Jingjing</creatorcontrib><creatorcontrib>Chen, Hefeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Weixia</au><au>Jin, Yiwen</au><au>Li, Juan</au><au>Huang, Jingjing</au><au>Chen, Hefeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease</atitle><jtitle>Pharmacogenomics</jtitle><addtitle>Pharmacogenomics</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>22</volume><issue>13</issue><spage>821</spage><epage>831</epage><pages>821-831</pages><issn>1462-2416</issn><eissn>1744-8042</eissn><abstract>The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear.
A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of
,
,
,
,
,
,
and
were genotyped using direct sequencing in all subjects.
The mutation of
rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in
and rs62293298 in
were also confirmed to be associated with hyperuricemia.
Age, weight, creatinine clearance rate, diuretics and SNPs on
,
and
were all risk factors of hyperuricemia.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>34505535</pmid><doi>10.2217/pgs-2021-0053</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0522-9923</orcidid><orcidid>https://orcid.org/0000-0002-0206-0766</orcidid><orcidid>https://orcid.org/0000-0002-2049-8729</orcidid><orcidid>https://orcid.org/0000-0002-8186-2045</orcidid></addata></record> |
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| issn | 1462-2416 1744-8042 |
| language | eng |
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| source | NCBI_PubMed Central（免费） |
| subjects | Adult Aged Asians ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics Case-Control Studies China - epidemiology Coronary Artery Disease - complications Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics coronary heart disease drug transporter gene Female Genetic Predisposition to Disease Genotype Glucose Transport Proteins, Facilitative - genetics Humans hyperuricemia Hyperuricemia - complications Hyperuricemia - epidemiology Hyperuricemia - genetics Male Middle Aged Mutation - genetics Neoplasm Proteins - genetics Organic Anion Transporters - genetics Organic Cation Transport Proteins - genetics Polymorphism, Single Nucleotide Risk Factors SNP |
| title | Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease |
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