Liposomes: Ideal drug delivery systems in breast cancer

Breast cancer (BC) has been recognized as the most common type of cancer in females across the world, accounting for 12% of each cancer case. In this sense, better diagnosis and screening have been thus far proven to contribute to higher survival rates. Moreover, traditional (or standard) chemothera...

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Bibliographic Details
Published in:Biotechnology and applied biochemistry 2022-10, Vol.69 (5), p.1867-1884
Main Authors: Forouhari, Sedighe, Beygi, Zahra, Mansoori, Zahra, Hajsharifi, Sara, Heshmatnia, Fatemeh, Gheibihayat, Seyed Mohammad
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biodegradation
Breast cancer
Cancer
Cancer therapies
Chemotherapy
Drug delivery
drug delivery system
Drug delivery systems
Drug therapy
Hydrophobicity
Immunogenicity
liposome
Liposomes
Selectivity
Survival
Toxicity
tumor
Tumors
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Summary:Breast cancer (BC) has been recognized as the most common type of cancer in females across the world, accounting for 12% of each cancer case. In this sense, better diagnosis and screening have been thus far proven to contribute to higher survival rates. Moreover, traditional (or standard) chemotherapy is still known as one of the several prominent therapeutic options available, though it suffers from unsuitable cell selectivity, severe consequences, as well as resistance. In this regard, nanobased drug delivery systems (DDSs) are likely to provide promising grounds for BC treatment. Liposomes are accordingly effective nanosystems, having the benefits of multiple formulations verified to treat different diseases. Such systems possess specific features, including smaller size, biodegradability, hydrophobic/hydrophilic characteristics, biocompatibility, lower toxicity, as well as immunogenicity, which can all lead to considerable efficacy in treating various types of cancer. As chemotherapy uses drugs to target tumors, generates higher drug concentrations in tumors, which can provide for their slow release, and enhances drug stability, it can be improved via liposomes in DDSs for BC treatment. Therefore, the present study aims to review the existing issues regarding BC treatment and discuss liposome‐based targeting in order to overcome barriers to conventional drug therapy. Types of nanoliposomes used in the treatment of breast cancer
ISSN:0885-4513
1470-8744
DOI:10.1002/bab.2253