Dinuclear gold(I) complexes with N -phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity

A small library of dinuclear gold(I) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2021-10, Vol.50 (38), p.13554-13560
Main Authors: Trevisan, Gianmarco, Vitali, Valentina, Tubaro, Cristina, Graiff, Claudia, Marchenko, Anatoliy, Koidan, Georgyi, Hurieva, Anastasiia N, Kostyuk, Aleksandr, Mauceri, Matteo, Rizzolio, Flavio, Accorsi, Gianluca, Biffis, Andrea
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Cell Line, Tumor
Cell Survival - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Coordination compounds
Crystallography, X-Ray
Gold
Gold - chemistry
Humans
Ligands
Luminescence
Methane - analogs & derivatives
Methane - chemistry
Molecular Conformation
Optical properties
Selectivity
Toxicity
Visible spectrum
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Summary:A small library of dinuclear gold(I) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting a rigid metallamacrocyclic structure can exhibit rather strong emissions that extend towards the red region of the visible spectrum. The anticancer activity of the complexes has been also preliminarly evaluated; cytotoxicity seems to correlate with complex lipophilicity, whereas selectivity towards cancer cells can be apparently enhanced upon a judicious choice of the ligands.
ISSN:1477-9226
1477-9234
DOI:10.1039/d1dt02444b