Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?

The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped pat...

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Bibliographic Details
Published in:Biomarkers in medicine 2021-10, Vol.15 (15), p.1377-1388
Main Author: Dhawan, Andrew
Format: Article
Language:English
Subjects:
Alzheimer’s disease
diagnostics
neurology
Parkinson’s disease
translational medicine
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Summary:The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Compared with healthy controls, in patients with Alzheimer’s disease, hsa-miR-767-5p was overexpressed (p 
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2021-0092