Functional Variants of miR-143 Are Associated with Schizophrenia Susceptibility: A Preliminary Population-Based Study and Bioinformatics Analysis

• Published in: Biochemical genetics 2022-06, Vol.60 (3), p.868-881
• Main Authors: Sargazi, Saman, Mirani Sargazi, Fariba, Heidari Nia, Milad, Sheervalilou, Roghayeh, Saravani, Ramin, Mirinejad, Shekoufeh, Shakiba, Mansoor
• Format: Article
• Language: English
• Subjects: Alleles; Biochemistry; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Computational Biology; ErbB-3 protein; Etiology; Gene expression; Genes; Genetic Predisposition to Disease; Genotyping; Haplotypes; Human Genetics; Humans; Iran; Medical Microbiology; Mental disorders; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Nucleotides; Original Article; Polymorphism, Single Nucleotide; Population studies; Population-based studies; Regulatory mechanisms (biology); Risk management; Risk reduction; Schizophrenia; Schizophrenia - genetics; Single-nucleotide polymorphism; Therapeutic applications; Zoology
• ISSN: 0006-2928; 1573-4927
• DOI: 10.1007/s10528-021-10133-z

Single nucleotide polymorphisms within genes encoding microRNAs may alter the expression of microRNAs and their target genes, contributing to the etiology of psychiatric disorders. We aimed to investigate the link between rs4705342T/C and rs4705343T/C polymorphisms in the promoter region of miR-143 and the risk of schizophrenia (SCZ) in a sample of an Iranian population. In this experimental study, a total of 398 subjects were recruited. Genotyping carried out using allele‐specific PCR (AS‐PCR) method. Different bioinformatics databases and Cytoscape V3.4.0 software were used for the analysis of the gene-miRNA interaction network. The genotypic analysis of rs4705342C/T showed that CC genotype in the co-dominant model significantly decreased the risk of SCZ ( p