Tin derived antimony/nitrogen-doped porous carbon (Sb/NPC) composite for electrochemical sensing of albumin from hepatocellular carcinoma patients

An electrochemical sensor based on an antimony/nitrogen-doped porous carbon (Sb/NPC) composite has been developed for the quantitative detection of albumin from hepatocellular carcinoma (HCC) patients. Sb/NPC is hydrothermally synthesized from Sn/NPC precursors. The synthesized precursor (Sn/NPC) an...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2021-10, Vol.188 (10), p.338-338, Article 338
Main Authors: Ashiq, Rabia, Fatima, Batool, Shah, Mohibullah, Hussain, Dilshad, Mohyuddin, Abrar, Majeed, Saadat, Mehmood, Rubaida, Imran, Muhammad, Ashiq, Muhammad Naeem, Najam-ul-Haq, Muhammad
Format: Article
Language:English
Subjects:
Albumin
Albumins
Analytical Chemistry
Antimony
Antimony - chemistry
Carbon - chemistry
Carcinoma, Hepatocellular - blood
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Electric properties
Electrochemical analysis
Electrochemical Techniques
Ethylenediaminetetraacetic acid
Glycoproteins
Hepatoma
Humans
Liver cancer
Liver Neoplasms - blood
Microengineering
Nanochemistry
Nanotechnology
Nitrogen - chemistry
Original Paper
Oxidation
Physiological aspects
Precursors
Sensors
Serum Albumin - analysis
Serum Albumin - chemistry
Statistical analysis
Statistical methods
Synthesis
Tin
Tin - chemistry
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Summary:An electrochemical sensor based on an antimony/nitrogen-doped porous carbon (Sb/NPC) composite has been developed for the quantitative detection of albumin from hepatocellular carcinoma (HCC) patients. Sb/NPC is hydrothermally synthesized from Sn/NPC precursors. The synthesized precursor (Sn/NPC) and the product (Sb/NPC) are characterized by XRD, FTIR, TGA, UV/Vis, SEM, and AFM. Cyclic voltammetry, chronoamperometry, and electrochemical impedance studies are used to investigate the electrochemical performance of Sb/NPC-GCE. Sb/NPC-GCE detects albumin at physiological pH of 7.4 in the potential range 0.92 V and 0.09 V for oxidation and reduction, respectively. LOD and recovery of Sb/NPC-GCE for the determination of albumin are 0.13 ng.mL −1 and 66.6  ±  0.97–100  ±  2.73%, respectively. Chronoamperometry of the modified working electrode demonstrates its stability for 14 h, indicating its reusability and reproducibility. Sb/NPC-GCE is a selective sensor for albumin detection in the presence of interfering species. The electrode has been applied for albumin detection in human serum samples of HCC patients. A negative correlation of albumin with alpha-fetoprotein levels in HCC patients is observed by statistical analysis. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-021-05005-7