Photosynthetic Cyanobacteria‐Hybridized Black Phosphorus Nanosheets for Enhanced Tumor Photodynamic Therapy

Photodynamic therapy (PDT) has attracted tremendous attention due to its advantages such as high safety and effectiveness compared to traditional radiotherapy and chemotherapy. However, the intratumoral hypoxic microenvironment will inevitably compromise the PDT effect of the highly oxygen‐dependent...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-10, Vol.17 (42), p.e2102113-n/a
Main Authors: Qi, Fenggang, Ji, Penghao, Chen, Zhixin, Wang, Liping, Yao, Heliang, Huo, Minfeng, Shi, Jianlin
Format: Article
Language:English
Subjects:
Biocompatibility
Bioreactors
black phosphorus nanosheets
Cyanobacteria
Microorganisms
Nanosheets
Nanotechnology
Oxygenation
Phosphorus
Photodynamic therapy
Photosynthesis
Radiation therapy
Singlet oxygen
Tumors
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Summary:Photodynamic therapy (PDT) has attracted tremendous attention due to its advantages such as high safety and effectiveness compared to traditional radiotherapy and chemotherapy. However, the intratumoral hypoxic microenvironment will inevitably compromise the PDT effect of the highly oxygen‐dependent type II photosensitizers, implicating the urgent demand for continuous intratumoral oxygenation. Herein, biocompatible photosynthetic cyanobacteria have been modified with inorganic two‐dimensional black phosphorus nanosheets (BPNSs) to be a novel bioreactor termed as Cyan@BPNSs. Upon 660 nm laser irradiation, the photosynthetic cyanobacteria generate oxygen continuously in situ through photosynthesis, followed by the photosensitization of BPNSs for activating oxygen into singlet oxygen (1O2), resulting in a large amount of 1O2 accumulation at the tumor site and the consequent strong tumor cell killing effect both in vitro and in vivo. This work provides an attractive strategy for efficient and biocompatible PDT, meanwhile extends the scope of microbiotic nanomedicine by hybridizing microorganisms with inorganic nanophotosensitizer. Photosynthetic cyanobacteria modified with inorganic two‐dimensional black phosphorus nanosheets (BPNSs) have been designed to be a novel bioreactor termed as Cyan@BPNSs. Under a single wavelength 660 nm laser source, biocompatible Cyan@BPNSs could exhibit photosynthesis‐enhanced photodynamic outcome and lead to effective photodynamic carcinoma destruction both in vitro and in vivo.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202102113