A Water Molecule Triggers Guest Exchange at a Mono‐Zinc Centre Confined in a Biomimetic Calixarene Pocket: A Model for Understanding Ligand Stability in Zn Proteins

Invited for the cover of this issue are Kristin Bartik, Olivia Reinaud and co‐workers at the Université libre de Bruxelles and Université Paris Descartes. The image depicts a Zn protein and highlights the role that a single water molecule can play in catalysing ligand exchange. Read the full text of...

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Bibliographic Details
Published in:Chemistry : a European journal 2021-10, Vol.27 (55), p.13663-13663
Main Authors: Brunetti, Emilio, Marcelis, Lionel, Zhurkin, Fedor E., Luhmer, Michel, Jabin, Ivan, Reinaud, Olivia, Bartik, Kristin
Format: Article
Language:English
Subjects:
Biomimetics
Calixarenes
Chemistry
Ligands
Proteins
Water chemistry
Zinc
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Summary:Invited for the cover of this issue are Kristin Bartik, Olivia Reinaud and co‐workers at the Université libre de Bruxelles and Université Paris Descartes. The image depicts a Zn protein and highlights the role that a single water molecule can play in catalysing ligand exchange. Read the full text of the article at 10.1002/chem.202102184. “This four‐step process explains the inertness of biological Zn centers where a five‐coordinate state is precluded.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 13730 ff. (DOI: 10.1002/chem.202102184).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202103240