Amniocentesis in twin gestation: the association between gestational age at procedure and complications

Purpose Third trimester amniocentesis is often performed when indications arise after 24 weeks of gestation—typically to investigate new sonographic findings, and might be related to pre-term birth. Scarcity of data exists concerning the risks of third-trimester amniocentesis in twin pregnancies. Me...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2022-05, Vol.305 (5), p.1169-1175
Main Authors: Wertheimer, Avital, Decter, Dean, Borovich, Adi, Trigerman, Shai, Bardin, Ron, Hadar, Eran, Krispin, Eyal
Format: Article
Language:English
Subjects:
Amniocentesis
Amniocentesis - adverse effects
Amniocentesis - methods
Amniotic fluid
Endocrinology
Female
Fetal Membranes, Premature Rupture - epidemiology
Fetal Membranes, Premature Rupture - etiology
Genetic counseling
Genetic disorders
Gestational Age
Gynecology
Hospitals
Human Genetics
Humans
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics
Obstetrics/Perinatology/Midwifery
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Trimester, Second
Pregnancy, Twin
Regression analysis
Retrospective Studies
Twins
Ultrasonic imaging
Women
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Summary:Purpose Third trimester amniocentesis is often performed when indications arise after 24 weeks of gestation—typically to investigate new sonographic findings, and might be related to pre-term birth. Scarcity of data exists concerning the risks of third-trimester amniocentesis in twin pregnancies. Methods A retrospective cohort study of all twin gestations that underwent amniocentesis in a tertiary hospital between 2007 and 2016. Outcomes and procedure-related complications were compared between third-trimester (≥ 24 weeks) and mid-trimester amniocentesis (16–23 weeks). Primary outcome was defined as membrane rupture within four weeks of procedure. Logistic regression analysis was utilized to adjust results to potential confounders. Results Overall, 185 eligible women were included, of them, 28 (15.1%) underwent third-trimester amniocentesis and 157 (84.9%) underwent mid-trimester amniocentesis. Women in the third-trimester amniocentesis group were younger and presented higher frequencies of intra-uterine growth restriction (31.5 vs. 35.3, p  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-021-06242-0