Combined effect of oral famotidine and cimetidine on the survival of lethally irradiated mice: An in vivo study

• Published in: Journal of cancer research and therapeutics 2021-07, Vol.17 (4), p.865-869
• Main Authors: dizaj, Karim, Monfared, Ali, Mozdarani, Hossein, Naeiji, Ali, Razzaghdoust, Abolfazl, Hajian-tilaki, Karimollah, Aboufazeli, Bahareh, Niksirat, Fatemeh, Borzoueisileh, Sajad
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Cimetidine; Cimetidine - administration & dosage; Cimetidine - pharmacology; Dosage and administration; Drug dosages; Drug therapy; Drug Therapy, Combination; Famotidine; Famotidine - administration & dosage; Famotidine - pharmacology; Histamine H2 Antagonists - administration & dosage; Histamine H2 Antagonists - pharmacology; Male; Mice; Radiation; Radiation injuries; Radiation Injuries - drug therapy; Radiation Injuries - etiology; Radiation Injuries - mortality; Survival Rate; Testing; Whole-Body Irradiation - adverse effects
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.JCRT_349_19

Aims: The study aims at evaluating the effects of the combinatory famotidine/cimetidine diet on radiated mice's survival. Materials and Methods: Two hundred and seventy male mice were categorized into 11 groups, a number of which were comprised of subgroups too. The groups under analysis were posed to varying doses of gamma-radiation, including 6, 7, 8, and 9 Gy, followed by treatments using various drug doses 2, 4, and 8 mg/kg, with survival fractions as long as a month after irradiation being measured and recorded. Results: LD50/30 was calculated as 7.47 Gy for the group with radiation only. Following mouse treatment with a concentration of 4 and 20 mg/kg for famotidine and cimetidine, respectively, the survival fraction for the mice grew significantly compared to LD50/30. The combinatory famotidine/cimetidine diet had a higher dose-reduction factor (DRF) than single doses of the drug in radioprotection. The DRF for combinatory famotidine/cimetidine, famotidine, and cimetidine diets was 08.09, 1.1, and 1.01, respectively. Conclusions: Results imply that the combined regimen of famotidine + cimetidine in radioprotection had no significant higher DRF than with regimens including each of them separately. In addition, we did not find a synergic effect of combined oral famotidine and cimetidine on irradiated mice.