Influence of adjuvant therapy on pattern of failure and survival in curatively resected gallbladder carcinoma

• Published in: Journal of cancer research and therapeutics 2021-07, Vol.17 (4), p.1064-1068
• Main Authors: Choudhary, Sunil, Gupta, Neha, Verma, Chandra, Das, Avipsa, Aggarwal, Lalit, Tewari, Mallika, Mandal, Abhijit, Asthana, Anupam
• Format: Article
• Language: English
• Subjects: Adjuvant treatment; Adult; Aged; Cancer; Care and treatment; Chemotherapy, Adjuvant - methods; Cholecystectomy - methods; Combined Modality Therapy; Excision (Surgery); Female; Follow-Up Studies; Gallbladder; Gallbladder cancer; Gallbladder Neoplasms - mortality; Gallbladder Neoplasms - pathology; Gallbladder Neoplasms - therapy; Humans; India; Male; Middle Aged; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Patient outcomes; Prognosis; Radiotherapy; Radiotherapy, Adjuvant - methods; Retrospective Studies; Survival Rate; Young Adult
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.JCRT_550_19

Purpose: The study was done to evaluate the role of adjuvant therapy in curatively resected Stage II and III gallbladder carcinoma (GBC). Materials and Methods: This was a retrospective analysis of patients of GBC registered between 2008 and 2017 in outpatient department of a tertiary cancer hospital in India. Patients who had any of the following adjuvant treatment after radical surgery: (a) external beam radiotherapy (RT) alone, (b) chemotherapy (CT) alone, and (c) RT with CT (CRT) were considered for the study. Results: A total of fifty patients could meet the selection criteria. It was seen that seven patients were treated with RT, 20 with CT, and 23 with CRT. Median follow-up for patients who were alive was 26.7 months. Nineteen patients had locoregional failure while eight had distant failure. Patients treated with CRT had a significantly better mean overall survival compared to those treated with RT or CT (44.0 months, 12.5 months, and 15.1 months, respectively; P = 0.003). Similarly, mean disease-free survival was superior in CRT arm compared to RT and CT arms (43.6 months, 9.6 months, and 12.4 months, respectively; P = 0.002). Conclusions: Adjuvant CRT had better survival outcome compared to patients treated with either RT or CT with Stage II and III disease after curative cholecystectomy.