Maximum contaminant level of arsenic in drinking water potentiates quinalphos-induced renal damage on co-administration of both arsenic and quinalphos in Wistar rats

This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats ea...

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Bibliographic Details
Published in:Environmental science and pollution research international 2020-06, Vol.27 (17), p.21331-21340
Main Authors: Singh, Parvinder, Verma, Pawan Kumar, Raina, Rajinder, Sood, Shilpa, Sharma, Priyanka
Format: Article
Language:English
Subjects:
Acetylcholinesterase
adults
antioxidant biomarkers
Antioxidants
Aquatic Pollution
Arsenic
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers
Catalase
Contaminants
Drinking water
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Glutathione
Glutathione peroxidase
Glutathione reductase
Glutathione transferase
glutathione-disulfide reductase
histopathology
Kidneys
Levels
maximum contaminant level
Peroxidase
Quinalphos
rats
Reductases
Research Article
Rodents
Superoxide dismutase
Thiobarbituric acid
Thiols
Tissues
Toxicants
Waste Water Technology
Water damage
Water Management
Water Pollution Control
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Summary:This study was designed to determine alterations in renal biomarkers, antioxidant profile, and histomorphology of renal tissue following subacute exposure to quinalphos alone or in conjunction with arsenic in rats. A total of 54 adult Wistar rats were randomly divided into nine groups of six rats each and were administered sub-lethal concentrations of quinalphos (1/100 th and 1/10 th of LD 50 ) orally daily and arsenic (50 and 100 ppb) in drinking water for 28 days. Significantly ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-020-08643-1