Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study

This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Results of semi-quantit...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2021-12, Vol.55, p.151815-151815, Article 151815
Main Authors: Dawoud, Marwa Mohammed, Aiad, Hayam Abd El Samie, Tawfiq, Eman Abd Elrazeq, Al-qalashy, Fatma Samir Ali, Eissa, Nehad, El-Rebey, Hala Said
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cadherins - metabolism
Carcinoma, Ovarian Epithelial - metabolism
Carcinoma, Ovarian Epithelial - pathology
E-Cadherin
Epithelial-Mesenchymal Transition
Epithelial-mesenchymal transition (EMT)
EYA2
Female
Homeodomain Proteins - metabolism
Humans
Immunohistochemistry
Intracellular Signaling Peptides and Proteins - metabolism
Middle Aged
Nuclear Proteins - metabolism
Ovarian cancer
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Prognosis
Protein Tyrosine Phosphatases - metabolism
Retrospective Studies
SIX1
Young Adult
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Summary:This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Results of semi-quantitative scoring were statistically compared, correlated with clinic-pathologic parameters, response to therapy and with patient survival. There was a significant association of SIX1 expression in the intratumoral stroma (ITS) with malignant cases (P 
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2021.151815