Lumped parameter models for two-ventricle and healthy and failing extracardiac Fontan circulations

Abstract Fontan circulations are surgical strategies to treat infants born with single ventricle physiology. Clinical and mathematical definitions of Fontan failure are lacking, and understanding is needed of parameters indicative of declining physiologies. Our objective is to develop lumped paramet...

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Bibliographic Details
Published in:Mathematical medicine and biology 2021-12, Vol.38 (4), p.442-466
Main Authors: Doyle, Matthew G, Chugunova, Marina, Roche, S Lucy, Keener, James P
Format: Article
Language:English
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Summary:Abstract Fontan circulations are surgical strategies to treat infants born with single ventricle physiology. Clinical and mathematical definitions of Fontan failure are lacking, and understanding is needed of parameters indicative of declining physiologies. Our objective is to develop lumped parameter models of two-ventricle and single-ventricle circulations. These models, their mathematical formulations and a proof of existence of periodic solutions are presented. Sensitivity analyses are performed to identify key parameters. Systemic venous and systolic left ventricular compliances and systemic capillary and pulmonary venous resistances are identified as key parameters. Our models serve as a framework to study the differences between two-ventricle and single-ventricle physiologies and healthy and failing Fontan circulations.
ISSN:1477-8599
1477-8602
DOI:10.1093/imammb/dqab012