Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper...

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Bibliographic Details
Published in:International journal of dermatology 2022-10, Vol.61 (10), p.1175-1186
Main Authors: Mintoff, Dillon, Benhadou, Farida, Pace, Nikolai P., Frew, John W.
Format: Article
Language:English
Subjects:
Epidemiology
Health risks
Inflammation
Literature reviews
Metabolic disorders
Metabolic syndrome
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Summary:Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.15910