Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Objective This study aims to compare the maternal serum delta neutrophil index (DNI) levels in intrahepatic cholestasis of pregnancy (ICP) and healthy pregnancies. Methods This study consisted of a group of patients (n = 40) diagnosed with isolated ICP who gave birth in our hospital and a control gr...

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Published in:The journal of obstetrics and gynaecology research 2021-12, Vol.47 (12), p.4189-4195
Main Authors: Eroğlu, Hasan, Şahin Uysal, Nihal, Sarsmaz, Kemal, Tonyalı, Nazan Vanlı, Codal, Bahadır, Yücel, Aykan
Format: Article
Language:English
Subjects:
Bile acids
Bile Acids and Salts
Cholestasis
Cholestasis, Intrahepatic
delta neutrophil index
Female
Gallbladder diseases
Humans
Infant, Newborn
Inflammation
inflammatory marker
Leukocytes (neutrophilic)
Neonates
Neutrophils
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Pruritus
Retrospective Studies
Statistical analysis
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Summary:Objective This study aims to compare the maternal serum delta neutrophil index (DNI) levels in intrahepatic cholestasis of pregnancy (ICP) and healthy pregnancies. Methods This study consisted of a group of patients (n = 40) diagnosed with isolated ICP who gave birth in our hospital and a control group (n = 60) between December 1, 2015, and June 30, 2018. The diagnosis of ICP was made based on pruritus and elevated fasting serum bile acids and liver enzymes. Laboratory tests of both groups in the hospitalization process were retrospectively examined. Maternal and neonatal characteristics, pregnancy outcomes, and DNI values of the two groups were compared. Statistical analyses were performed using SPSS version 20. Results Mean maternal serum DNI levels were significantly higher in women with ICP than in the control group (0.49 ± 4.8 vs –3.99 ± 3.02, p = 
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15028