Statistical shape analysis of putamen in early-onset Parkinson’s disease

• Published in: Clinical neurology and neurosurgery 2021-10, Vol.209, p.106936-106936, Article 106936
• Main Authors: Sigirli, Deniz, Ozdemir, Senem Turan, Erer, Sevda, Sahin, Ibrahim, Ercan, Ilker, Ozpar, Rifat, Orun, Muhammet Okay, Hakyemez, Bahattin
• Format: Article
• Language: English
• Subjects: Adult; Age; Alzheimer's disease; Brain; Early-onset; Female; Humans; Magnetic Resonance Imaging; Male; Mental disorders; Middle Aged; Movement disorders; Neurodegenerative diseases; Neurology; Organ Size - physiology; Parkinson Disease - diagnostic imaging; Parkinson's disease; Patients; Putamen; Putamen - diagnostic imaging; Statistical shape analysis
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2021.106936

To investigate the shape differences in the putamen of early-onset Parkinson’s patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities. This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson’s patients and age and gender matched control subjects. Landmark coordinate data obtained and Procrustes analysis was used to compare mean shapes. The relationships between the centroid sizes of the left and right putamen, and the durations of disease examined using growth curve models. While there was a significant difference between the right putamen shape of control and patient groups, there was not found a significant difference in terms of left putamen. Sub-regional analyses showed that for the right putamen, the most prominent deformations were localized in the middle-posterior putamen and minimal deformations were seen in the anterior putamen. Although they were not as pronounced as those in the right putamen, the deformations in the left putamen mimic the deformations in the right putamen which are found mainly in the middle-posterior putamen and at a lesser extend in the anterior putamen. •There was a significant difference between the right putamen shape of control and early-onset Parkinson’s disease groups.•There was no significant difference in terms of left putamen between the two groups.•The most prominent deformations were localized in the middle-posterior putamen.