Antihypertensive and antihyperlipemic of spirulina (Arthrospira platensis) sauce on patients with hypertension: A randomized triple‐blind placebo‐controlled clinical trial

• Published in: Phytotherapy research 2021-11, Vol.35 (11), p.6181-6190
• Main Authors: Ghaem Far, Zohreh, Babajafari, Siavash, Kojuri, Javad, Mohammadi, Salman, Nouri, Mehran, Rostamizadeh, Pouya, Rahmani, Mohammad Hossein, Azadian, Mohsen, Ashrafi‐Dehkordi, Elham, Zareifard, Alireza, Golchin Vafa, Reza, Mazloomi, Seyed Mohammad
• Format: Article
• Language: English
• Subjects: Antihypertensives; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Clinical trials; Congestive heart failure; Coronary artery disease; Diuretics; Food cans; functional food; Functional foods & nutraceuticals; Heart diseases; Hypertension; Kidney diseases; lipid profile; Low density lipoprotein; Patients; Placebos; Renal failure; Risk analysis; Risk factors; Spirulina; Triglycerides
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.7254

Systemic arterial hypertension is an independent risk factor for coronary heart disease, stroke, heart failure, and chronic kidney diseases. Spirulina is microalgae with nutritious ingredients and has potential attenuating effects on chronic diseases including hypertension. Spirulina can be added to food products in order to develop functional foods. The aim of this study was to assess the effects of 8‐week consumption of a salad dressing containing 2 g of spirulina platensis powder versus a placebo dressing on patients with hypertension. In this triple‐blind randomized clinical trial, 48 patients with hypertension were enrolled to receive daily either spirulina‐fortified dressing or placebo for 2 months. A total of 41 patients completed this study. We observed that the consumption of spirulina dressing significantly reduced systolic blood pressure (p = .02), diastolic blood pressure (p = .03), serum triglyceride (p = .01), total cholesterol, and low‐density lipoprotein (LDL) levels, compared to nonsignificant changes in the placebo group. Significant changes in TAC and hs‐CRP levels were observed in none of the groups. According to our findings, spirulina‐fortified dressing as a functional food can be used a supportive treatment for patients with hypertension along with standard antihypertensive drugs. However, further investigations are required for a more comprehensive conclusion.