Changes in Hemoglobin Isoforms in the Peripheral Blood of Rats with Experimental Posthemorrhagic Anemia

Six hemoglobin isoforms were identified in the peripheral blood of male Wistar rats by PAAG electrophoresis. Erythrocytes can be separated into 6 fractions by fractional centrifugation; the fractions differ by the content of reticulocytes and cells with fetal hemoglobin. Cells in each fraction conta...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-08, Vol.171 (4), p.421-424
Main Authors: Yushkov, B. G., Brilliant, S. A., Minin, A. S.
Format: Article
Language:English
Subjects:
Anemia
Anemia - blood
Anemia - etiology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Centrifugation
Chemical properties
Disease Models, Animal
Erythrocyte Count
Erythrocytes
Erythrocytes - chemistry
Erythrocytes - metabolism
Erythropoiesis
Fetuses
Glycosylated hemoglobin
Hemoglobin
Hemoglobins - analysis
Hemoglobins - metabolism
Hemorrhage - blood
Hemorrhage - complications
Internal Medicine
Isoforms
Laboratory Medicine
Male
Pathology
Peripheral blood
Protein Isoforms - analysis
Protein Isoforms - blood
Rats
Rats, Wistar
Reticulocytes
Rodents
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Summary:Six hemoglobin isoforms were identified in the peripheral blood of male Wistar rats by PAAG electrophoresis. Erythrocytes can be separated into 6 fractions by fractional centrifugation; the fractions differ by the content of reticulocytes and cells with fetal hemoglobin. Cells in each fraction contain one light and one heavy hemoglobin isoforms, and their combination is specific to each fraction. Changes in the hemoglobin isoforms in the whole blood in case of blood loss can be associated with changes in physical and chemical properties of circulating erythrocytes, as well as with the formation of various cell populations resulting from activated erythropoiesis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05241-0