Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China

Objective Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are e...

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Bibliographic Details
Published in:Current medical science 2021-10, Vol.41 (5), p.888-893
Main Authors: Nie, Ying-li, Song, Ze-xing, Tao, Juan, Han, Xu, Yang, Liu
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
China
Female
Fibrin Fibrinogen Degradation Products - metabolism
Gastrointestinal Diseases - blood
Gastrointestinal Diseases - etiology
Hospitalization
Humans
IgA Vasculitis - blood
IgA Vasculitis - complications
Kidney Diseases - blood
Kidney Diseases - etiology
Leukocyte Count
Lipoproteins, HDL - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Receptors, Immunologic - blood
Retrospective Studies
Young Adult
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Summary:Objective Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV. Methods A retrospective analysis was performed for adult IgAV patients, who were hospitalized in Wuhan Union Hospital between January 2016 and December 2019. A total of 259 patients were enrolled, and the pre-treatment serological markers were comprehensively assessed. Results In the present study, 49.0% and 33.2% of patients developed renal and gastrointestinal (GI) involvement, respectively. Furthermore, the elevated levels of white blood cells count, D-Dimer (D-D), C-reactive protein (CRP) and neutrophil granulocyte ratio (NE%) >60% were significantly associated with GI involvement in the univariate analysis, while the decrease in high density lipoprotein level, and the elevated D-D and CRP levels were significantly associated with renal involvement ( P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-021-2440-0