The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats

Adhesions in rat abdominal cavity were studied after laparotomy and subsequent single intraperitoneal injection of 2 ml of 5% aqueous solution of oxidized dextran (OD) with a molecular weight of 40 kDa (oxidation degree 10%). On days 7 and 21 after laparotomy, the number of adhesions in OD-treated r...

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Published in:Bulletin of experimental biology and medicine 2021-08, Vol.171 (4), p.416-420
Main Authors: Karpov, M. A., Shkurupy, V. A., Troitskii, A. V.
Format: Article
Language:English
Subjects:
Abdominal Cavity - pathology
Abdominal Cavity - surgery
Adhesions
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Collagen
Dextran
Dextrans - administration & dosage
Dextrans - pharmacology
Disease Models, Animal
Fibroblasts
Injections, Intraperitoneal
Internal Medicine
Laboratory Medicine
Laparotomy
Laparotomy - adverse effects
Leukocytes (neutrophilic)
Male
Molecular weight
Oxidation
Pathology
Peritoneum
Peritoneum - drug effects
Peritoneum - pathology
Postoperative Complications - prevention & control
Rats
Rats, Wistar
Tissue Adhesions - prevention & control
Treatment Outcome
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description Adhesions in rat abdominal cavity were studied after laparotomy and subsequent single intraperitoneal injection of 2 ml of 5% aqueous solution of oxidized dextran (OD) with a molecular weight of 40 kDa (oxidation degree 10%). On days 7 and 21 after laparotomy, the number of adhesions in OD-treated rats was lower by 7.5 and 4 times than in animals not receiving OD. The number of neutrophils in adhesions on day 21 was manyfold lower in OD-treated rats. In 7 and 21 days after laparotomy, the number of fibroblasts in the adhesions of rats receiving and not receiving OD was similar, but 2-fold higher than in the peritoneum of non-operated rats. The content of collagen in adhesions on day 21 after laparotomy in OD-treated rats was 10-fold lower than in animals no receiving OD.
doi_str_mv 10.1007/s10517-021-05240-1
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subjects Abdominal Cavity - pathology
Abdominal Cavity - surgery
Adhesions
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Collagen
Dextran
Dextrans - administration & dosage
Dextrans - pharmacology
Disease Models, Animal
Fibroblasts
Injections, Intraperitoneal
Internal Medicine
Laboratory Medicine
Laparotomy
Laparotomy - adverse effects
Leukocytes (neutrophilic)
Male
Molecular weight
Oxidation
Pathology
Peritoneum
Peritoneum - drug effects
Peritoneum - pathology
Postoperative Complications - prevention & control
Rats
Rats, Wistar
Tissue Adhesions - prevention & control
Treatment Outcome
title The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats
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