New Xanthones with Antiagricultural Fungal Pathogen Activities from the Endophytic Fungus Diaporthe goulteri L17

• Published in: Journal of agricultural and food chemistry 2021-09, Vol.69 (38), p.11216-11224
• Main Authors: Peng, Xiaoping, Sun, Fusheng, Li, Gang, Wang, Cong, Zhang, Yuhan, Wu, Changzheng, Zhang, Chunyang, Sun, Yong, Wu, Siyi, Zhang, Yuxiang, Zong, Hui, Guo, Rui, Lou, Hongxiang
• Format: Article
• Language: English
• Subjects: Agricultural and Environmental Chemistry
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.1c03513

Six new xanthone dimers, diaporxanthones A–F (1–6), and an unusual xanthone monomer diaporxanthone G (7), in addition to seven known analogues (8–14), were isolated and identified from endophytic Diaporthe goulteri L17 harbored in the fruits of the salt-tolerant plant Vitex trifolia. The chemical structures of these metabolites were elucidated on the basis of nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and reported data in the literature. Their absolute configurations were established by single-crystal X-ray diffraction analysis together with time-dependent density functional theory electronic circular dichroism calculations. Among these compounds, compounds 1 and 6 exhibited moderate antifungal activities against Nectria sp. and Colletotrichum musae and compound 4 showed significant cytotoxicity against all selected five cancer cell lines.