Changes in Total Homocysteine and Glutathione Levels After Laparoscopic Sleeve Gastrectomy in Children with Metabolic-Associated Fatty Liver Disease

Purpose Paediatric obesity is a well-known risk factor for metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the levels of total homocysteine (tHcy) and total glutathione (tGSH) plasma levels in children wi...

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Bibliographic Details
Published in:Obesity surgery 2022, Vol.32 (1), p.82-89
Main Authors: Pastore, Anna, Panera, Nadia, Mosca, Antonella, Caccamo, Romina, Camanni, Daniela, Crudele, Annalisa, De Stefanis, Cristiano, Alterio, Arianna, Di Giovamberardino, Gianna, De Vito, Rita, Francalanci, Paola, Battaglia, Sonia, Muda, Andrea Onetti, De Peppo, Francesco, Alisi, Anna
Format: Article
Language:English
Subjects:
Child
Gastrectomy - adverse effects
Gastrointestinal surgery
Glutathione
Homocysteine
Humans
Laparoscopy
Laparoscopy - adverse effects
Liver diseases
Medicine
Medicine & Public Health
Metabolism
Non-alcoholic Fatty Liver Disease - complications
Obesity
Obesity, Morbid - surgery
Original Contributions
Pediatric Obesity - complications
Pediatric Obesity - surgery
Surgery
Treatment Outcome
Ultrasonic imaging
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Summary:Purpose Paediatric obesity is a well-known risk factor for metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the levels of total homocysteine (tHcy) and total glutathione (tGSH) plasma levels in children with MAFLD. Material and Methods Twenty-four children with severe obesity who underwent LSG were included in the study. The metabolic parameters, systemic inflammatory markers, one-carbon metabolism products, ultrasound and histological improvement were evaluated at baseline (T0M) and after 12 months from LSG (T12M). Results The patients exhibited a significant amelioration of several metabolic parameters at T12M. A significant reduction of steatosis was observed at ultrasound (from 72.7% of moderate-severe grade to 0% severe steatosis), accompanied by a statistically significant improvement of ballooning, portal and lobular inflammation and fibrosis. A statistically significant decrease of tumour necrosis factor circulating levels was also observed (T0M median = 290.3, IQR = 281.0–317.0 pg/mL; T12M median = 260.4, IQR = 240.0–279.0 pg/mL; p  
ISSN:0960-8923
1708-0428
1708-0428
DOI:10.1007/s11695-021-05701-6