Clinical Factors Related to Loculation of Fluid in Central Serous Chorioretinopathy

To elucidate clinical factors related to the presence of loculation of fluid (LOF) in the posterior choroid in central serous chorioretinopathy (CSC). Retrospective, cross-sectional study. This single-center study included 158 eyes from 158 patients with CSC who were classified into LOF and non-LOF...

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Published in:American journal of ophthalmology 2022-03, Vol.235, p.197-203
Main Authors: Imanaga, Naoya, Terao, Nobuhiro, Sawaguchi, Shota, Tamashiro, Tamaki, Wakugawa, Sorako, Yamauchi, Yukihide, Koizumi, Hideki
Format: Article
Language:English
Subjects:
Body fluids
Central Serous Chorioretinopathy - diagnosis
Choroid
Cross-Sectional Studies
Edema
Fluorescein Angiography - methods
Humans
Male
Medical imaging
Ophthalmology
Photography
Retina
Retrospective Studies
Software
Tomography, Optical Coherence - methods
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Summary:To elucidate clinical factors related to the presence of loculation of fluid (LOF) in the posterior choroid in central serous chorioretinopathy (CSC). Retrospective, cross-sectional study. This single-center study included 158 eyes from 158 patients with CSC who were classified into LOF and non-LOF groups. The groups were compared for age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. Using swept-source optical coherence tomography (OCT), we determined the presence of LOF based on B-scan and en face images. Scleral thickness was measured 6 mm posterior to the scleral spur in 4 directions using anterior-segment OCT. The 158 eyes were classified into 98 eyes in the LOF group and 60 eyes in the non-LOF group. In univariable analyses, the LOF group was younger (P = .01) and had a higher male ratio (P = .03) and greater SCT (P < .001) than the non-LOF group. All scleral thicknesses at the superior, temporal, inferior, and nasal points were greater in the LOF group than in the non-LOF group (426.2 vs 395.1 μm, 445.7 vs 414.9 μm, 459.2 vs 428.8 μm, 445.4 vs 414.3 μm, all P < .05). Multivariable analyses found that SCT (odds ratio [OR] 1.02, 95% CI 1.01-1.02, P < .001) and mean scleral thickness (OR 1.02, 95% CI 1.02-1.03, P = .002) were significantly associated with the presence of LOF. A thick choroid and thick sclera appeared to be related to the presence of LOF in CSC.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2021.09.009