Adenoid ameloblastoma with dentinoid is molecularly different from ameloblastomas and adenomatoid odontogenic tumors

Background Adenoid ameloblastoma is a rare epithelial neoplasm, histologically characterized by the presence of ameloblastoma‐like features, duct‐like structures, epithelial whorls, and cribriform architecture. Dentinoid material is usually present. Some advocate adenoid ameloblastoma is an amelobla...

Full description

Saved in:
Bibliographic Details
Published in:Journal of oral pathology & medicine 2021-11, Vol.50 (10), p.1067-1071
Main Authors: Coura, Bruna Pizziolo, Santos, Jean Nunes, Fonseca, Felipe Paiva, Bernardes, Vanessa Fátima, Aquino, Sibele Nascimento, Jorge Júnior, Jacks, Vargas, Pablo Agustin, Romañach, Mário José, Andrade, Bruno Augusto Benevenuto, Gomez, Ricardo Santiago, Gomes, Carolina Cavalieri
Format: Article
Language:English
Subjects:
Adenoid
adenoid ameloblastoma
Adenoids
Ameloblastoma
Ameloblastoma - genetics
BRAF
genetics
Humans
KRAS
Mutation
mutations
Neoplasms, Glandular and Epithelial
Odontogenic tumors
Odontogenic Tumors - genetics
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins p21(ras) - genetics
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Adenoid ameloblastoma is a rare epithelial neoplasm, histologically characterized by the presence of ameloblastoma‐like features, duct‐like structures, epithelial whorls, and cribriform architecture. Dentinoid material is usually present. Some advocate adenoid ameloblastoma is an ameloblastoma variant. However, there are overlapping features not only with ameloblastoma, but also with adenomatoid odontogenic tumor. Most ameloblastomas are characterized by the presence of BRAF p.V600E mutations and adenomatoid odontogenic tumors harbor signature KRAS mutations. The molecular features of adenoid ameloblastoma remain unknown. Methods Nine adenoid ameloblastoma cases were screened by TaqMan allele‐specific qPCR to assess BRAF p.V600E, ameloblastoma signature mutation, and KRAS p.G12V and p.G12R, adenomatoid odontogenic tumor signature mutations. Results BRAF and KRAS mutations were not detected in any of the adenoid ameloblastoma cases. Conclusion The molecular results support adenoid ameloblastoma as an entity distinct from adenomatoid odontogenic tumor and ameloblastoma.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13243