Serum Neurofilament Light: a Potential Diagnostic and Prognostic Biomarker in Obstetric Posterior Reversible Encephalopathy Syndrome

Obstetric posterior reversible encephalopathy syndrome (PRES), caused by preeclampsia (PE) or eclampsia, is a clinical imaging syndrome and a critical maternal complication, with vasogenic edema in white matter as a typical imaging characteristic. Serum neurofilament light (NFL) is a marker of neuro...

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Bibliographic Details
Published in:Molecular neurobiology 2021-12, Vol.58 (12), p.6460-6470
Main Authors: Fang, Xiaobo, Liang, Yanling, Zhang, Weixi, Wang, Qiong, Chen, Jingsi, Chen, Jia, Lin, Yongqiang, Chen, Yanli, Yu, Li, Wang, Haibin, Chen, Dunjin
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood Pressure - physiology
Cell Biology
Eclampsia
Edema
Encephalopathy
Female
Humans
Magnetic resonance imaging
Neurobiology
Neurofilament Proteins - blood
Neurology
Neurosciences
Obstetrics
Patients
Posterior Leukoencephalopathy Syndrome - blood
Posterior Leukoencephalopathy Syndrome - diagnosis
Pre-eclampsia
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - diagnosis
Pregnancy Outcome
Prognosis
Retrospective Studies
Substantia alba
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Summary:Obstetric posterior reversible encephalopathy syndrome (PRES), caused by preeclampsia (PE) or eclampsia, is a clinical imaging syndrome and a critical maternal complication, with vasogenic edema in white matter as a typical imaging characteristic. Serum neurofilament light (NFL) is a marker of neuroaxonal injury. Therefore, we performed this study to explore the diagnostic and prognostic role of NFL in obstetric PRES. We used stored serum samples and clinical data obtained from 2148 PE or eclampsia patients from the Guangzhou Medical Centre for Critical Pregnant Women from January 2015 to January 2020. The serum NFL concentration was measured by Simoa assay. Patients without complete data and MRI examinations were excluded. All patients were grouped into the PRES and non-PRES groups based on the PRES diagnostic criteria. In total, 222 patients met the inclusion criteria and were grouped into the PRES ( n  = 123) and non-PRES ( n  = 99) groups. The NFL level was significantly higher in the PRES group than in the non-PRES group ( p  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-021-02562-z