Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells

To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerate...

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Bibliographic Details
Published in:Zhōnghuá xuèyèxué zázhì 2021-08, Vol.42 (8), p.660
Main Authors: Dong, X Y, Li, Y L, Wu, C Y, Shang, B J, Zhang, L, Cheng, W, Zhu, Z M
Format: Article
Language:Chinese
Subjects:
Blast Crisis
Chromosome Aberrations
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Prognosis
Retrospective Studies
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Summary:To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. ①Among the 348 patients with primary CML-CP, 20 patients (5.75% ) had ACA, including 3 and 17 patients with high-risk and non-high-risk ACA, respectively, whereas the remaining 328 patients did not h
ISSN:0253-2727
DOI:10.3760/cma.j.issn.0253-2727.2021.08.008