Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells

To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerate...

Full description

Saved in:
Bibliographic Details
Published in:Zhōnghuá xuèyèxué zázhì 2021-08, Vol.42 (8), p.660
Main Authors: Dong, X Y, Li, Y L, Wu, C Y, Shang, B J, Zhang, L, Cheng, W, Zhu, Z M
Format: Article
Language:Chinese
Subjects:
Blast Crisis
Chromosome Aberrations
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Prognosis
Retrospective Studies
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 8
container_start_page 660
container_title Zhōnghuá xuèyèxué zázhì
container_volume 42
creator Dong, X Y
Li, Y L
Wu, C Y
Shang, B J
Zhang, L
Cheng, W
Zhu, Z M
description To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. ①Among the 348 patients with primary CML-CP, 20 patients (5.75% ) had ACA, including 3 and 17 patients with high-risk and non-high-risk ACA, respectively, whereas the remaining 328 patients did not h
doi_str_mv 10.3760/cma.j.issn.0253-2727.2021.08.008
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2575373703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2575373703</sourcerecordid><originalsourceid>FETCH-LOGICAL-p126t-8122ecc3a4ae0d9d9ea57dca4cbbb5d6b97be88a2f16a974665814430dfe51ff3</originalsourceid><addsrcrecordid>eNo9UMtOwzAQ9AFEq9JfQD72kuDYcZweEeIlIcEBztXa3rSGxA5xAurH8K8YKJx2tDuzs7OErAqWC1Wxc9NB_pK7GH3OuBQZV1zlnPEiZ3XOWH1E5v_9GVnG6DSThahqIdgJmYlSlqpWfE4-Lzy0--giDQ01rfPOQEsbhHEaMFLwlvZD2PpwoPQwOvRjpB9u3FGzG0JS0G6PbdiiD1OkLU6v2DmgOxh0GJzfUrDWjS4kpx9FF2LoEgbtw5BAmiUr5-njLuuT0ejekRps23hKjhtoIy4PdUGer6-eLm-z-4ebu8uL-6wveDVmdcE5GiOgBGR2bdcIUlkDpdFaS1vptdJY18CbooK1KqtK1kVZCmYblEXTiAVZ_e5NWd8mjOOmc_H7AvCYMm24VFIooZhI1LMDddId2k0_uA6G_ebvpeILqF2B0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2575373703</pqid></control><display><type>article</type><title>Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells</title><source>PubMed Central</source><creator>Dong, X Y ; Li, Y L ; Wu, C Y ; Shang, B J ; Zhang, L ; Cheng, W ; Zhu, Z M</creator><creatorcontrib>Dong, X Y ; Li, Y L ; Wu, C Y ; Shang, B J ; Zhang, L ; Cheng, W ; Zhu, Z M</creatorcontrib><description>To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. ①Among the 348 patients with primary CML-CP, 20 patients (5.75% ) had ACA, including 3 and 17 patients with high-risk and non-high-risk ACA, respectively, whereas the remaining 328 patients did not h</description><identifier>ISSN: 0253-2727</identifier><identifier>DOI: 10.3760/cma.j.issn.0253-2727.2021.08.008</identifier><identifier>PMID: 34547872</identifier><language>chi</language><publisher>China</publisher><subject>Blast Crisis ; Chromosome Aberrations ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Prognosis ; Retrospective Studies</subject><ispartof>Zhōnghuá xuèyèxué zázhì, 2021-08, Vol.42 (8), p.660</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34547872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, X Y</creatorcontrib><creatorcontrib>Li, Y L</creatorcontrib><creatorcontrib>Wu, C Y</creatorcontrib><creatorcontrib>Shang, B J</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Cheng, W</creatorcontrib><creatorcontrib>Zhu, Z M</creatorcontrib><title>Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells</title><title>Zhōnghuá xuèyèxué zázhì</title><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><description>To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. ①Among the 348 patients with primary CML-CP, 20 patients (5.75% ) had ACA, including 3 and 17 patients with high-risk and non-high-risk ACA, respectively, whereas the remaining 328 patients did not h</description><subject>Blast Crisis</subject><subject>Chromosome Aberrations</subject><subject>Humans</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0253-2727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9UMtOwzAQ9AFEq9JfQD72kuDYcZweEeIlIcEBztXa3rSGxA5xAurH8K8YKJx2tDuzs7OErAqWC1Wxc9NB_pK7GH3OuBQZV1zlnPEiZ3XOWH1E5v_9GVnG6DSThahqIdgJmYlSlqpWfE4-Lzy0--giDQ01rfPOQEsbhHEaMFLwlvZD2PpwoPQwOvRjpB9u3FGzG0JS0G6PbdiiD1OkLU6v2DmgOxh0GJzfUrDWjS4kpx9FF2LoEgbtw5BAmiUr5-njLuuT0ejekRps23hKjhtoIy4PdUGer6-eLm-z-4ebu8uL-6wveDVmdcE5GiOgBGR2bdcIUlkDpdFaS1vptdJY18CbooK1KqtK1kVZCmYblEXTiAVZ_e5NWd8mjOOmc_H7AvCYMm24VFIooZhI1LMDddId2k0_uA6G_ebvpeILqF2B0g</recordid><startdate>20210814</startdate><enddate>20210814</enddate><creator>Dong, X Y</creator><creator>Li, Y L</creator><creator>Wu, C Y</creator><creator>Shang, B J</creator><creator>Zhang, L</creator><creator>Cheng, W</creator><creator>Zhu, Z M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20210814</creationdate><title>Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells</title><author>Dong, X Y ; Li, Y L ; Wu, C Y ; Shang, B J ; Zhang, L ; Cheng, W ; Zhu, Z M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-8122ecc3a4ae0d9d9ea57dca4cbbb5d6b97be88a2f16a974665814430dfe51ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2021</creationdate><topic>Blast Crisis</topic><topic>Chromosome Aberrations</topic><topic>Humans</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Dong, X Y</creatorcontrib><creatorcontrib>Li, Y L</creatorcontrib><creatorcontrib>Wu, C Y</creatorcontrib><creatorcontrib>Shang, B J</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Cheng, W</creatorcontrib><creatorcontrib>Zhu, Z M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, X Y</au><au>Li, Y L</au><au>Wu, C Y</au><au>Shang, B J</au><au>Zhang, L</au><au>Cheng, W</au><au>Zhu, Z M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells</atitle><jtitle>Zhōnghuá xuèyèxué zázhì</jtitle><addtitle>Zhonghua Xue Ye Xue Za Zhi</addtitle><date>2021-08-14</date><risdate>2021</risdate><volume>42</volume><issue>8</issue><spage>660</spage><pages>660-</pages><issn>0253-2727</issn><abstract>To investigate the effects of additional chromosomal abnormalities (ACA) in Philadelphia chromosome-positive (Ph(+)) cells on biological characteristics, therapy efficacy, and prognosis of patients with primary chronic myeloid leukemia (CML) -chronic phase (CP) and those who developed CML-accelerated phase/blast phase (AP/BP) during therapy. The clinical data of 410 patients with Ph(+) CML, including 348 patients with primary CML-CP and 62 patients who progressed to CML-AP/BP during treatment, who were admitted to Henan People's Hospital from January 2013 to June 2020 were retrospectively analyzed to categorize into high-risk, non-high-risk, and non-ACA groups according to the ELN2020 criteria. The effects of high- and non-high-risk ACA on biological characteristics, therapy efficacy, and prognosis were compared. ①Among the 348 patients with primary CML-CP, 20 patients (5.75% ) had ACA, including 3 and 17 patients with high-risk and non-high-risk ACA, respectively, whereas the remaining 328 patients did not h</abstract><cop>China</cop><pmid>34547872</pmid><doi>10.3760/cma.j.issn.0253-2727.2021.08.008</doi></addata></record>
fulltext fulltext
identifier ISSN: 0253-2727
ispartof Zhōnghuá xuèyèxué zázhì, 2021-08, Vol.42 (8), p.660
issn 0253-2727
language chi
recordid cdi_proquest_miscellaneous_2575373703
source PubMed Central
subjects Blast Crisis
Chromosome Aberrations
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Prognosis
Retrospective Studies
title Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T02%3A32%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20clinical%20features%20and%20prognosis%20of%20patients%20with%20chronic%20myelogenous%20leukemia%20harboring%20additional%20chromosomal%20abnormalities%20in%20Ph-positive%20cells&rft.jtitle=Zh%C5%8Dnghu%C3%A1%20xu%C3%A8y%C3%A8xu%C3%A9%20z%C3%A1zh%C3%AC&rft.au=Dong,%20X%20Y&rft.date=2021-08-14&rft.volume=42&rft.issue=8&rft.spage=660&rft.pages=660-&rft.issn=0253-2727&rft_id=info:doi/10.3760/cma.j.issn.0253-2727.2021.08.008&rft_dat=%3Cproquest_pubme%3E2575373703%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p126t-8122ecc3a4ae0d9d9ea57dca4cbbb5d6b97be88a2f16a974665814430dfe51ff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2575373703&rft_id=info:pmid/34547872&rfr_iscdi=true