Association between neutrophil percentage-to-albumin ratio and contrast-associated acute kidney injury in patients without chronic kidney disease undergoing percutaneous coronary intervention

•We assessed neutrophil percentage-to-albumin ratio (NPAR) on admission in patients without chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI).•High NPAR (>15.7) was associated with contrast-associated acute kidney injury.•High NPAR (>15.7) was an independent pred...

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Published in:Journal of cardiology 2022-02, Vol.79 (2), p.257-264
Main Authors: He, Hao-Ming, Zhang, Si-Cheng, He, Chen, You, Zhe-Bin, Luo, Man-Qing, Lin, Mao-Qing, Lin, Xue-Qin, Zhang, Li-Wei, Lin, Kai-Yang, Guo, Yan-Song
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Albumins
Contrast Media - adverse effects
Contrast-associated acute kidney injury
Creatinine
Humans
Mortality
Neutrophil percentage-to-albumin ratio
Neutrophils
Percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Renal Insufficiency, Chronic - complications
Retrospective Studies
Risk Factors
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Summary:•We assessed neutrophil percentage-to-albumin ratio (NPAR) on admission in patients without chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI).•High NPAR (>15.7) was associated with contrast-associated acute kidney injury.•High NPAR (>15.7) was an independent predictor of long-term mortality.•NPAR may assist risk stratification in patients without CKD undergoing PCI. Neutrophil and albumin are well-known biomarkers of inflammation, which are highly related to contrast-associated acute kidney injury (CA-AKI). We aim to explore the predictive value of neutrophil percentage-to-albumin ratio (NPAR) for CA-AKI and long-term mortality in patients without chronic kidney disease (CKD) undergoing elective percutaneous coronary intervention (PCI). We retrospectively observed 5083 consenting patients from January 2012 to December 2018. CA-AKI was defined as an increase in serum creatinine ≥50% or 0.3 mg/dL within 48 h after contrast medium exposure. The incidence of CA-AKI was 5.6% (n=286). The optimal cut-off value of NPAR for predicting CA-AKI was 15.7 with 66.8% sensitivity and 61.9% specificity [C statistic=0.679; 95% confidence interval (CI), 0.666-0.691]. NPAR displayed higher area under the curve values in comparison to neutrophil percentage (p 
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2021.09.004