Regulation of innate immune signaling pathways by autophagy in dengue virus infection

Autophagy is not only an intracellular recycling degradation system that maintains cellular homeostasis but is also a component of innate immunity that contributes to host defense against viral infection. The viral components as well as viral particles trapped in autophagosomes can be delivered to l...

Full description

Saved in:
Bibliographic Details
Published in:IUBMB life 2022-02, Vol.74 (2), p.170-179
Main Authors: Wan, Shu‐Wen, Lee, Ying‐Ray, Ho, Tzong‐Shiann, Chang, Chih‐Peng
Format: Article
Language:English
Subjects:
Antiviral activity
antiviral immunity
Autophagy
Dengue - genetics
Dengue fever
Dengue Virus
Homeostasis
Humans
Immunity, Innate
innate immune response
Innate immunity
Interferon
Lysosomes
Pattern recognition receptors
Phagosomes
Replication
Signal Transduction
Viral infections
viral replication
Virus Diseases
Virus Replication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autophagy is not only an intracellular recycling degradation system that maintains cellular homeostasis but is also a component of innate immunity that contributes to host defense against viral infection. The viral components as well as viral particles trapped in autophagosomes can be delivered to lysosomes for degradation. Abundant evidence indicates that dengue virus (DENV) has evolved the potent ability to hijack or subvert autophagy process for escaping host immunity and promoting viral replication. Moreover, autophagy is often required to deliver viral components to pattern recognition receptors signaling for interferon (IFN)‐mediated viral elimination. Hence, this review summarizes DENV‐induced autophagy, which exhibits dual effects on proviral activity of promoting replication and antiviral activity to eliminating viral particles.
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.2554