Joint Associations between Plasma 25-Hydroxyvitamin D, Glycemic Status, and First Stroke in General Hypertensive Adults: Results from the China Stroke Primary Prevention Trial (CSPPT)

• Published in: The Journal of nutrition 2022-01, Vol.152 (1), p.246-254
• Main Authors: Wei, Yaping, Xu, Benjamin, Wang, Zhuo, Zhou, Ziyi, Liu, Lishun, Lin, Tengfei, Song, Yun, Li, Jianping, Zhang, Yan, Huo, Yong, Mao, Guangyun, Wang, Binyan, Tang, Genfu, Qin, Xianhui, Zhang, Hao, Wang, Xiaobin, Guo, Huiyuan, Xu, Xiping
• Format: Article
• Language: English
• Subjects: 25-hydroxyvitamin D; Adult; Adults; Blood; Blood Glucose; China - epidemiology; Diabetes; Diabetes mellitus; fasting blood glucose; first stroke; Glucose; Health risks; Hemorrhage; Humans; Hyperglycemia; Hypertension; Hypertension - epidemiology; hypertensive adults; Hypoglycemic agents; Ischemia; ischemic stroke; Nutrition; Population studies; Prevention; Primary Prevention; Quartiles; Regression analysis; Regression models; Risk analysis; Risk Factors; Stroke; Stroke - epidemiology; Stroke - etiology; Stroke - prevention & control; Vitamin D; Vitamin D - analogs & derivatives
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/nxab339

Associations between vitamin D and stroke remain inconsistent. One major risk factor for stroke is high blood glucose, but the role it plays in this association is not well studied. We aimed to evaluate the individual association between plasma 25-hydroxyvitamin D [25(OH)D] and risk of first stroke stratified by fasting blood glucose (FBG), and the joint associations between plasma 25(OH)D, glycemic status, and first stroke in hypertensive adults. This study was a nested, case-control design utilizing data from the China Stroke Primary Prevention Trial (CSPPT). This analysis included 591 first stroke cases (of which 475 were ischemic stroke, 114 were hemorrhagic stroke, and 2 were uncertain type) and 591 matched controls. The age range of the study population was 45–75 y. The normal FBG (NFG) group had FBG