Reference intervals for end-tidal carbon monoxide of preterm neonates

Objectives We constructed reference intervals for end-tidal carbon monoxide (ETCOc) levels of neonates 28 0/7 to 34 6/7 weeks gestation in order to assess hemolytic rate. Study design This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA. Results Of 226 attempted measurements, 92...

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Published in:Journal of perinatology 2022-01, Vol.42 (1), p.116-120
Main Authors: Pakdeeto, Sasikarn, Christensen, Thomas R., Bahr, Timothy M., Gerday, Erick, Sheffield, Mark J., Christensen, Kyle S., Supapannachart, Sarayut, Nuntnarumit, Pracha, Sukwiset, Saranya, Ohls, Robin K., Christensen, Robert D.
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Language:English
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692/53/2421
692/53/2422
692/699/1541
Birth
Breath Tests
Carbon monoxide
Carbon Monoxide - analysis
Female
Gestation
Hemolysis
Humans
Infant, Newborn
Infant, Premature
Intensive care
Intervals
Medicine
Medicine & Public Health
Neonatal care
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Pregnancy
Premature babies
Premature birth
Prospective Studies
Reference Values
Thailand
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container_start_page 116
container_title Journal of perinatology
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creator Pakdeeto, Sasikarn
Christensen, Thomas R.
Bahr, Timothy M.
Gerday, Erick
Sheffield, Mark J.
Christensen, Kyle S.
Supapannachart, Sarayut
Nuntnarumit, Pracha
Sukwiset, Saranya
Ohls, Robin K.
Christensen, Robert D.
description Objectives We constructed reference intervals for end-tidal carbon monoxide (ETCOc) levels of neonates 28 0/7 to 34 6/7 weeks gestation in order to assess hemolytic rate. Study design This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA. Results Of 226 attempted measurements, 92% were successful. Values from day 1 through 28 were charted and upper (>95th percentile) reference interval limits calculated. During the entire 28 days, the ETCOc upper reference intervals from babies in Bangkok were higher than those in Utah ( p   0.1). Similar to term neonates, preterm neonates in Bangkok and Utah had higher ETCOc values during the first 48 h after birth than thereafter ( p  
doi_str_mv 10.1038/s41372-021-01207-2
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Study design This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA. Results Of 226 attempted measurements, 92% were successful. Values from day 1 through 28 were charted and upper (&gt;95th percentile) reference interval limits calculated. During the entire 28 days, the ETCOc upper reference intervals from babies in Bangkok were higher than those in Utah ( p  &lt; 0.01). No differences were found due to sex, or earliest vs. latest gestation at birth (both p  &gt; 0.1). Similar to term neonates, preterm neonates in Bangkok and Utah had higher ETCOc values during the first 48 h after birth than thereafter ( p  &lt; 0.01). Conclusions Using this methodology, and the reference interval chart, the hemolytic rate of preterm infants ≥28 weeks can be assessed.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-021-01207-2</identifier><identifier>PMID: 34556800</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/53/2421 ; 692/53/2422 ; 692/699/1541 ; Birth ; Breath Tests ; Carbon monoxide ; Carbon Monoxide - analysis ; Female ; Gestation ; Hemolysis ; Humans ; Infant, Newborn ; Infant, Premature ; Intensive care ; Intervals ; Medicine ; Medicine &amp; Public Health ; Neonatal care ; Neonates ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Premature babies ; Premature birth ; Prospective Studies ; Reference Values ; Thailand</subject><ispartof>Journal of perinatology, 2022-01, Vol.42 (1), p.116-120</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-32b85da605945c15b573a1366ba443ebc6314981b87f0bd92f60a48706bf91a03</citedby><cites>FETCH-LOGICAL-c375t-32b85da605945c15b573a1366ba443ebc6314981b87f0bd92f60a48706bf91a03</cites><orcidid>0000-0002-7946-0290 ; 0000-0003-4587-9445 ; 0000-0003-2865-8878 ; 0000-0001-5872-582X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34556800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pakdeeto, Sasikarn</creatorcontrib><creatorcontrib>Christensen, Thomas R.</creatorcontrib><creatorcontrib>Bahr, Timothy M.</creatorcontrib><creatorcontrib>Gerday, Erick</creatorcontrib><creatorcontrib>Sheffield, Mark J.</creatorcontrib><creatorcontrib>Christensen, Kyle S.</creatorcontrib><creatorcontrib>Supapannachart, Sarayut</creatorcontrib><creatorcontrib>Nuntnarumit, Pracha</creatorcontrib><creatorcontrib>Sukwiset, Saranya</creatorcontrib><creatorcontrib>Ohls, Robin K.</creatorcontrib><creatorcontrib>Christensen, Robert D.</creatorcontrib><title>Reference intervals for end-tidal carbon monoxide of preterm neonates</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objectives We constructed reference intervals for end-tidal carbon monoxide (ETCOc) levels of neonates 28 0/7 to 34 6/7 weeks gestation in order to assess hemolytic rate. Study design This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA. Results Of 226 attempted measurements, 92% were successful. Values from day 1 through 28 were charted and upper (&gt;95th percentile) reference interval limits calculated. During the entire 28 days, the ETCOc upper reference intervals from babies in Bangkok were higher than those in Utah ( p  &lt; 0.01). No differences were found due to sex, or earliest vs. latest gestation at birth (both p  &gt; 0.1). Similar to term neonates, preterm neonates in Bangkok and Utah had higher ETCOc values during the first 48 h after birth than thereafter ( p  &lt; 0.01). Conclusions Using this methodology, and the reference interval chart, the hemolytic rate of preterm infants ≥28 weeks can be assessed.</description><subject>692/53/2421</subject><subject>692/53/2422</subject><subject>692/699/1541</subject><subject>Birth</subject><subject>Breath Tests</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - analysis</subject><subject>Female</subject><subject>Gestation</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive care</subject><subject>Intervals</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neonatal care</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Thailand</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKBDEQRYMoOj5-wIU0uHETrbx7liLjAwRBdB2S7mppmU7GpEf07804PsCFq1rUubeKQ8ghg1MGoj7LkgnDKXBGgXEwlG-QCZNGU6Wk2CQTMFLQWki9Q3ZzfgZYLc022RFSKV0DTMjsHjtMGBqs-jBienXzXHUxVRhaOvatm1eNSz6GaoghvvUtVrGrFgkLO1QBY3Aj5n2y1ZUgHnzNPfJ4OXu4uKa3d1c3F-e3tBFGjVRwX6vWaVBTqRqmvDLCMaG1d1IK9I0WTE5r5mvTgW-nvNPgZG1A-27KHIg9crLuXaT4ssQ82qHPDc7nrnyyzJYro3VpgBV6_Ad9jssUyneWa85FzQRjheJrqkkx54SdXaR-cOndMrAryXYt2RbJ9lOy5SV09FW99AO2P5FvqwUQayCXVXjC9Hv7n9oPfHaFaQ</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Pakdeeto, Sasikarn</creator><creator>Christensen, Thomas R.</creator><creator>Bahr, Timothy M.</creator><creator>Gerday, Erick</creator><creator>Sheffield, Mark J.</creator><creator>Christensen, Kyle S.</creator><creator>Supapannachart, Sarayut</creator><creator>Nuntnarumit, Pracha</creator><creator>Sukwiset, Saranya</creator><creator>Ohls, Robin K.</creator><creator>Christensen, Robert D.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7946-0290</orcidid><orcidid>https://orcid.org/0000-0003-4587-9445</orcidid><orcidid>https://orcid.org/0000-0003-2865-8878</orcidid><orcidid>https://orcid.org/0000-0001-5872-582X</orcidid></search><sort><creationdate>20220101</creationdate><title>Reference intervals for end-tidal carbon monoxide of preterm neonates</title><author>Pakdeeto, Sasikarn ; 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Study design This is a prospective four-NICU study in Bangkok, Thailand, and Utah, USA. Results Of 226 attempted measurements, 92% were successful. Values from day 1 through 28 were charted and upper (&gt;95th percentile) reference interval limits calculated. During the entire 28 days, the ETCOc upper reference intervals from babies in Bangkok were higher than those in Utah ( p  &lt; 0.01). No differences were found due to sex, or earliest vs. latest gestation at birth (both p  &gt; 0.1). Similar to term neonates, preterm neonates in Bangkok and Utah had higher ETCOc values during the first 48 h after birth than thereafter ( p  &lt; 0.01). 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source Springer Nature; Nexis
subjects 692/53/2421
692/53/2422
692/699/1541
Birth
Breath Tests
Carbon monoxide
Carbon Monoxide - analysis
Female
Gestation
Hemolysis
Humans
Infant, Newborn
Infant, Premature
Intensive care
Intervals
Medicine
Medicine & Public Health
Neonatal care
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Pregnancy
Premature babies
Premature birth
Prospective Studies
Reference Values
Thailand
title Reference intervals for end-tidal carbon monoxide of preterm neonates
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