Impact of bronchial wall thickness on airflow obstruction in bronchiectasis

•Bronchial wall thickening made respiratory reactance more negative in bronchiectasis.•Bronchial wall thickening deteriorated the severity of airflow obstruction.•Abnormal respiratory reactance might affect airflow obstruction in bronchiectasis. The association between airflow obstruction and bronch...

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Published in:Respiratory physiology & neurobiology 2022-01, Vol.295, p.103788-103788, Article 103788
Main Authors: Yamamoto, Yuji, Kuge, Tomoki, Miki, Keisuke, Tsujino, Kazuyuki, Kawasaki, Takahiro, Matsuki, Takanori, Miki, Mari, Mori, Masahide, Kida, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Bronchi - diagnostic imaging
Bronchi - pathology
Bronchiectasis - physiopathology
Female
Forced oscillation technique
Humans
Lung Diseases, Obstructive - physiopathology
Male
Middle Aged
Physiology
Pulmonary Ventilation - physiology
Radiology
Reactance
Retrospective Studies
Spirometry
Tomography, X-Ray Computed
Ventilation
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Summary:•Bronchial wall thickening made respiratory reactance more negative in bronchiectasis.•Bronchial wall thickening deteriorated the severity of airflow obstruction.•Abnormal respiratory reactance might affect airflow obstruction in bronchiectasis. The association between airflow obstruction and bronchial dilation has been researched in bronchiectasis. However, the impact of bronchial wall thickening on airflow obstruction has not been thoroughly investigated. This study assessed the underlying mechanism of airflow obstruction in bronchiectasis due to abnormal bronchial wall thickening using oscillometry. A total of 98 patients with bronchiectasis were retrospectively reviewed. At the time of diagnosis, spirometric and oscillometric parameters, high-resolution computed tomography scores, and clinical characteristics were collected. The bronchial diameter, bronchial wall thickness, and extent of emphysema were evaluated semi-quantitatively. Correlations between patient data and characteristics were analyzed. Thirty-three patients with airflow obstruction showed higher respiratory resistance, more negative respiratory reactance (Xrs) at 5 Hz (X5), and higher bronchial wall thickness score than those without airflow obstruction. The bronchial wall thickness score negatively affected forced expiration volume in 1 s /forced vital capacity and X5. Abnormal bronchial wall thickening might make Xrs more negative and progress airflow obstruction in bronchiectasis.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2021.103788