Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways

• Published in: Neuroscience letters 2021-11, Vol.765, p.136263-136263, Article 136263
• Main Authors: Sehati, Fardin, Ahmadi, Iraj, Farivar, Nika, Ranjbaran, Mina, Sadat-Shirazi, Mitra-sadat, Nabavizadeh, Fatemeh, Mahla Shavakandi, Seyyedeh, Ashabi, Ghorbangol
• Format: Article
• Language: English
• Subjects: Aged; Aging - immunology; Animals; Apoptosis; Brain - diagnostic imaging; Brain - drug effects; Brain - immunology; Cerebral hypoperfusion; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - immunology; Disease Models, Animal; Humans; Ischemia; Locomotion - drug effects; Locomotion - immunology; Male; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Neuroinflammatory Diseases - diagnosis; Neuroinflammatory Diseases - immunology; Neuroinflammatory Diseases - prevention & control; Neuroprotective Agents - administration & dosage; NF-E2-Related Factor 2 - metabolism; Nrf2; Oxidative Stress - drug effects; Oxidative Stress - immunology; Positron-Emission Tomography; Rat; Rats; Tannic acid; Tannins - administration & dosage
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2021.136263

[Display omitted] •Tannic acid improves brain metabolism and blood flow in oligemia.•Tannic acid decreases neurodegeneration level after hypoperfusion.•Tannic acid exhibits protective effects against locomotion and working memory deficit. Current study purposed to investigate the neuroprotective effects of Tannic Acid (TA) on mild chronic cerebral hypoperfusion model in rats. Male Wistar rats were subjected to permanent Unilateral Common Carotid Artery Occlusion (UCCAO), followed by TA treatment (0.05% w/v) in drinking water for one month. Nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H: quinone oxidoreductase 1 (NQO-1), heme oxygenase-1 (HO-1), factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3, blood triglyceride, blood glucose, and liver enzymes’ activity were detected after the experimental period. Also, behavioral tests, hematoxylin and eosin (H&E) staining, and PET scan were performed after treatment. Post-treatment of TA improved locomotion and memory function (P