Regulatory interplay between microRNAs and WNT pathway in glioma

Glioma is one of the most common neoplasms of the central nervous system with a poor survival. Due to the obstacles in treating this disease, a part of recent studies mainly focuses on identifying the underlying molecular mechanisms that contribute to its malignancy. Altering microRNAs (miRNAs) expr...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2021-11, Vol.143, p.112187-112187, Article 112187
Main Authors: Tabnak, Peyman, Mafakheri, Asrin, Haji Emsailpoor, Zanyar, Kazemi, Tohid, Shekari, Najibeh
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Brain Neoplasms - drug therapy
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
circRNA
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Glioma
Glioma - drug therapy
Glioma - genetics
Glioma - metabolism
Glioma - pathology
Humans
lncRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
WNT
Wnt Signaling Pathway - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioma is one of the most common neoplasms of the central nervous system with a poor survival. Due to the obstacles in treating this disease, a part of recent studies mainly focuses on identifying the underlying molecular mechanisms that contribute to its malignancy. Altering microRNAs (miRNAs) expression pattern has been identified obviously in many cancers. Through regulating various targets and signaling pathways, miRNAs play a pivotal role in cancer progression. As one of the essential signaling pathways, WNT pathway is dysregulated in many cancers, and a growing body of evidence emphasis its dysregulation in glioma. Herein, we provide a comprehensive review of miRNAs involved in WNT pathway in glioma. Moreover, we show the interplay between miRNAs and WNT pathway in regulating different processes such as proliferation, invasion, migration, radio/chemotherapy resistance, and epithelial-mesenchymal-transition. Then, we introduce several drugs and treatments against glioma, which their effects are mediated through the interplay of WNT pathway and miRNAs. [Display omitted] •Aberrantly expressed miRNAs are implicated in WNT pathway dysregulation in glioma.•This dysregulation contributes to therapy resistance and EMT in glioma cells.•Circular and long non-coding RNAs can act as upstream regulators for these miRNAs.•miRNAs involved in regulating AKT pathway can also affect WNT/β-catenin pathway.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.112187