T‐cell subsets in the skin and their role in inflammatory skin disorders

T lymphocytes (T cells) are major players of the adaptive immune response. Naive T cells are primed in the presence of cytokines, leading to polarization into distinct T‐cell subsets with specific functions. These subsets are classified based on their T‐cell receptor profile, expression of transcrip...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2022-03, Vol.77 (3), p.827-842
Main Authors: Kortekaas Krohn, Inge, Aerts, Joeri L., Breckpot, Karine, Goyvaerts, Cleo, Knol, Edward, Van Wijk, Femke, Gutermuth, Jan
Format: Article
Language:English
Subjects:
Adaptive immunity
Chemokine receptors
Cytokines
Cytokines - metabolism
Humans
Hypersensitivity
Inflammation
Inflammatory diseases
inflammatory skin disorders
Lymphocytes
Lymphocytes T
Pathophysiology
Receptor mechanisms
Skin - pathology
Skin diseases
Skin Diseases - etiology
T cells
T-Lymphocyte Subsets
Transcription factors
Tumors
T‐cell subsets
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Summary:T lymphocytes (T cells) are major players of the adaptive immune response. Naive T cells are primed in the presence of cytokines, leading to polarization into distinct T‐cell subsets with specific functions. These subsets are classified based on their T‐cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and their cytokine production, which together determine their specific function. This review provides an overview of the various T‐cell subsets and their function in several inflammatory skin disorders ranging from allergic inflammation to skin tumors. Moreover, we highlight similarities of T‐cell responses across different skin disorders, demonstrating the presence of similar and opposing functions for the different T‐cell subsets. Finally, we discuss the effects of currently available and promising therapeutic approaches to harness T cells in inflammatory skin diseases for which efficacy next to unwanted side effects provide new insights into the pathophysiology of skin disorders.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.15104