Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray

Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-lo...

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Bibliographic Details
Published in:Carbohydrate polymers 2021-12, Vol.273, p.118543-118543, Article 118543
Main Authors: Arauzo, Beatriz, Lobera, M. Pilar, Monzon, Antonio, Santamaria, Jesus
Format: Article
Language:English
Subjects:
A549 Cells
Administration, Inhalation
Anti-Bacterial Agents - pharmacology
Antimicrobial
Chitosan
Chitosan - chemistry
Chitosan - pharmacology
Ciprofloxacin
Ciprofloxacin - administration & dosage
Ciprofloxacin - chemistry
Ciprofloxacin - pharmacology
Dry powder
Electrospray
Humans
Lung Diseases - drug therapy
Lung Diseases - metabolism
Microbial Sensitivity Tests
Particle Size
Powders - administration & dosage
Powders - chemistry
Powders - pharmacology
Pseudomonas aeruginosa - drug effects
Pulmonary administration
Spectroscopy, Fourier Transform Infrared - methods
Staphylococcus aureus - drug effects
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Summary:Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 ± 248.5 nm and 501.1 ± 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa. [Display omitted] •Respirable ciprofloxacin-loaded chitosan sub-micron particles are generated as dry powder by electrospray.•The particles show high antimicrobial activity against S. aureus and P. aeruginosa.•Good biocompatibility with alveolar cell line
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2021.118543