Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016)

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2021-11, Vol.15 (6), p.102280-102280, Article 102280
• Main Authors: Liberty, Iche A., Kodim, Nasrin, Sartika, Ratu A.D., Trihandini, Indang, Tjekyan, R.M. Suryadi, Zulkarnain, Pane, Masdalina, Pratisthita, Livy B., Tahapary, Dicky L., Soewondo, Pradana
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Blood Glucose - analysis; Case-Control Studies; Conversion; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Female; Follow-Up Studies; Glucose; Humans; Indonesia - epidemiology; Middle Aged; Prediabetic State - diagnosis; Prediabetic State - epidemiology; Prediabetic State - metabolism; Prognosis; Reproductive; Retrospective Studies; Risk Factors; ROC Curve; Triglycerides - blood; TyG index; Women; Young Adult
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2021.102280

Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. This study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was 4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia. •Conversion of glucose homeostasis in women at reproductive age•Insulin resistance as a risk of type 2 diabetes melitus in women at reproductive age•Assessment of insulin resistance in limited healthcare facilities using triglyceride/glucose index•Progression and regression of prediabetes state in women at reproductive age