Platelet Function Tests Predicting the Efficacy and Safety of Aspirin Secondary Prevention

To precisely prevent stroke, we evaluated three platelet function tests and their associations with clinical outcomes in ischemic stroke patients. On-treatment platelet reactivity of acute minor stroke patients taking aspirin plus clopidogrel was tested by light transmittance aggregometry (LTA), thr...

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Bibliographic Details
Published in:Neurological research (New York) 2022-04, Vol.44 (4), p.291-298
Main Authors: Cheng, Yue, Shao, Tengfei, Huang, Lili, Xu, Hengheng, Shao, Pengfei, Yang, Dan, Ge, Weihong, Xu, Yun, Zhang, Meijuan
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aspirin - adverse effects
Aspirin - pharmacology
Blood Platelets - drug effects
Cerebral Hemorrhage - chemically induced
Clopidogrel - pharmacology
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
ischemic stroke
Ischemic Stroke - prevention & control
Male
Middle Aged
Outcome Assessment, Health Care
Platelet Aggregation Inhibitors - adverse effects
Platelet Aggregation Inhibitors - pharmacology
Platelet Function Tests
Secondary Prevention
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Summary:To precisely prevent stroke, we evaluated three platelet function tests and their associations with clinical outcomes in ischemic stroke patients. On-treatment platelet reactivity of acute minor stroke patients taking aspirin plus clopidogrel was tested by light transmittance aggregometry (LTA), thromboelastography (TEG) and platelet function analyzer (PFA). Mann-Whitney U tests and receiver operating characteristic (ROC) curve analysis were used to assess their associations with recurrent events and clinical outcome prediction. 127 acute minor stroke patients were stringently selected and followed for 13 months. Eight patients (6.3%) self-reported the recurrence and 13 (10.2%) patients self-reported bleeding. Recurrent patients displayed significantly higher on-treatment platelet reactivity when measured with LTA (p = 0.030) and PFA (p
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.2021.1981103