Copper()-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides

Cu( ii )-mediated C-H sulphenylation or selenylation of Trp indole by a derivative of cysteine or selenocysteine enables access to the tryptathionine unit or its selenium congener. The mechanism of these protocols, which allow macrocyclization of Trp-containing peptides, has been studied. Cu( ii )-m...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (82), p.1763-1766
Main Authors: Kobayashi, Daishiro, Kohmura, Yutaka, Hayashi, Junya, Denda, Masaya, Tsuchiya, Koichiro, Otaka, Akira
Format: Article
Language:English
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Summary:Cu( ii )-mediated C-H sulphenylation or selenylation of Trp indole by a derivative of cysteine or selenocysteine enables access to the tryptathionine unit or its selenium congener. The mechanism of these protocols, which allow macrocyclization of Trp-containing peptides, has been studied. Cu( ii )-mediated C-H sulphenylation or selenylation of Trp enabling the formation of a (seleno)cysteine-linkage was developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc04856b