Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair

Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthes...

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Bibliographic Details
Published in:Nanoscale 2021-10, Vol.13 (39), p.1668-16689
Main Authors: Wang, Li, Zeng, Xiyang, Yan, Guilong, Chen, Xiaohu, Luo, Kun, Zhou, Shiyi, Zhang, Peicong, Li, Junfeng, Wong, Tuck-Whye
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Biomimetics
Hydroxyapatite
Mechanical properties
Orthopedics
Polytetrahydrofuran
Regeneration (physiology)
Scaffolds
Shape memory
Surgical implants
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Summary:Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthesized with programmable pore structures, based on poly( -caprolactone) (PCL), polytetrahydrofuran (PTMG) and the osteoconductive hydroxyapatite (HA). The obtained scaffolds presented various pore structures, high connectivity, tunable mechanical properties, and excellent shape memory performance. Moreover, the mineralization activity of the developed scaffolds could enhance the formation of hydroxyapatite and they showed good biocompatibility in vitro . The in vivo experiments show that scaffolds could promote the formation of new bone in critical size cranial defects. The programmable porous scaffold biomaterials exhibited potential application promise in bone regeneration. The pore structure programmability of PUHA scaffolds could be varied by adjusting the HA content and they present excellent cell toxicity and bone conductivity.
ISSN:2040-3364
2040-3372
DOI:10.1039/d1nr04124j