A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV–Vis spectroscopy

Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra ( Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an ir...

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Bibliographic Details
Published in:Photochemical & photobiological sciences 2021-11, Vol.20 (11), p.1381-1395
Main Authors: de Oliveira, Lucas N., do Nascimento, Eriberto O., Caldas, Linda V. E.
Format: Article
Language:English
Subjects:
Biochemistry
Biomaterials
Chemistry
Chemistry and Materials Science
Humans
Light
Original Papers
Photochemotherapy
Photosensitizing Agents
Physical Chemistry
Plant Sciences
Spectrophotometry
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Summary:Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra ( Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an irradiator containing a blue LED bulb lamp was utilized. The CHS samples were irradiated with ten doses from 0.60 up to 6.0 kJ/cm 2 , and six concentrations were prepared (1, 2, 3, 4, 5, and 6 mg/ml) for the CHS detector samples. After irradiation, the detector samples were evaluated using UV–Vis spectrophotometry. The results showed the behavior of the CHS detector with doses and concentrations, its sensitivity, and its linearity was also evaluated both by Wavelength Method (WM) and the Kernel Principal Component Regression (KPCR) Statistical Method. The values obtained indicate that this method can be applied to the CHS sample detector. In conclusion, the CHS is a promising detector in the field of photodynamic therapy.
ISSN:1474-905X
1474-9092
DOI:10.1007/s43630-021-00088-w