Cis-Isomers of Photosensitive Cationic Azobenzene Surfactants in DNA Solutions at Different NaCl Concentrations: Experiment and Modeling

The DNA interaction with cis-isomers of photosensitive azobenzene-containing surfactants was studied by both experimental methods and computer simulation. It was shown that before the organization of micelles, such surfactants in the cis-conformation form associates of only a single type with a diso...

Full description

Saved in:
Bibliographic Details
Published in:The journal of physical chemistry. B 2021-10, Vol.125 (40), p.11197-11207
Main Authors: Silanteva, Irina A, Komolkin, Andrei V, Mamontova, Veronika V, Gabrusenok, Pavel V, Vorontsov-Velyaminov, Pavel N, Santer, Svetlana, Kasyanenko, Nina A
Format: Article
Language:English
Subjects:
B: Biophysical and Biochemical Systems and Processes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The DNA interaction with cis-isomers of photosensitive azobenzene-containing surfactants was studied by both experimental methods and computer simulation. It was shown that before the organization of micelles, such surfactants in the cis-conformation form associates of only a single type with a disordered orientation of molecules. In contrast, for trans-isomers, there exist two types of associates with head-to-head or head-to-tail orientations of molecules in dependence on salt concentration in a solution. The comparison of cis- and trans-isomer binding to DNA and the influence of salt concentration on the formation of their complexes with DNA were studied. It was shown that cis-isomers interact with phosphate groups of DNA and that their molecules were also located along the minor groove of DNA.
ISSN:1520-6106
1520-5207
DOI:10.1021/acs.jpcb.1c07864