Single and joint impact of type 2 diabetes and of congestive heart failure on albuminuria

• Published in: Journal of diabetes and its complications 2021-12, Vol.35 (12), p.108046-108046, Article 108046
• Main Authors: Saely, Christoph H., Maechler, Maximilian, Vonbank, Alexander, Sprenger, Lukas, Mader, Arthur, Larcher, Barbara, Zanolin-Purin, Daniela, Leiherer, Andreas, Muendlein, Axel, Drexel, Heinz
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Aged; Albuminuria; Albuminuria - etiology; Antihypertensives; Blood pressure; Body mass index; Cardiovascular disease; Cholesterol; Congestive heart failure; Creatinine; Creatinine - urine; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - complications; Diabetic nephropathy; Ejection fraction; Fasting; Female; Heart failure; Heart Failure - complications; High density lipoprotein; Humans; Hypertension; Male; Middle Aged; Regression analysis; Statins; Type 2 diabetes; Urine
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2021.108046

Albuminuria is a characteristic feature of diabetic nephropathy, and urine albumin excretion is also increased in patients with congestive heart failure (CHF). However, no data are available on the single and joint associations of type 2 diabetes mellitus (T2DM) and CHF with albuminuria. This issue was addressed in the present study. We investigated 4 groups of patients: 180 patients with CHF, of whom 83 had T2DM (CHF+/T2DM+) and 97 did not have diabetes (CHF+/T2DM-) and 223 controls without CHF, of whom 39 had T2DM (CHF-/T2DM+) and 184 did not have diabetes (CHF-/T2DM-). The albumin-creatinine ratio (ACR) was 9.2 [5.7–16.9] mg/g in CHF-/T2DM- patients. Compared to this group it was higher in CHF-/T2DM+ patients (16.1 [7.7–27.8] mg/g; p = 0.004), in CHF+/T2DM- patients (22.0 [9.0–76.8] mg/g; p