Antifungal peptides from the marine gorgonian-associated fungus Aspergillus sp. SCSIO41501

Three undescribed cyclic lipopeptides maribasins C-E and four undescribed linear peptides aspergillipeptides H–K together with three known analogous maribasins A-B and marihysin A were isolated from the marine gorgonian-associated fungus Aspergillus sp. SCSIO 41501 (Trichocomaceae). Their structures...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2021-12, Vol.192, p.112967-112967, Article 112967
Main Authors: Yao, Fei-Hua, Liang, Xiao, Cheng, Xia, Ling, Juan, Dong, Jun-De, Qi, Shu-Hua
Format: Article
Language:English
Subjects:
Antifungal
Aspergillus sp
Cyclic lipopeptide
Linear peptide
Marine-derived fungus
Trichocomaceae
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Summary:Three undescribed cyclic lipopeptides maribasins C-E and four undescribed linear peptides aspergillipeptides H–K together with three known analogous maribasins A-B and marihysin A were isolated from the marine gorgonian-associated fungus Aspergillus sp. SCSIO 41501 (Trichocomaceae). Their structures were determined by spectroscopic analysis, and their absolute configurations were further confirmed by Marfey's methods. Maribasins C-E and maribasins A-B showed significant antifungal activity against five phytopathogenic fungal strains with MIC values of 3.12–50 μg/disc. Structure-bioactivity relationship exhibited that the β-amino fatty acid chain could significantly affect the antifungal activity of this type of cyclic lipopeptides. [Display omitted] •Ten peptides were isolated from the fungus Aspergillus sp.•Their absolute configurations were determined by Marfey's methods.•Five cyclic lipopeptides showed significant antifungal activity against five phytopathogens.•Structure-bioactivity relationship was discussed.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2021.112967