Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance

An antibody–drug conjugate (ADC) is an advanced chemotherapeutic option with immense promises in treating many tumor. They are designed to selectively attack and kill neoplastic cells with minimal toxicity to normal tissues. ADCs are complex engineered immunoconjugates that comprise a monoclonal ant...

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Bibliographic Details
Published in:Clinical & translational oncology 2022-03, Vol.24 (3), p.407-431
Main Authors: Murali, M., Kumar, A. R., Nair, B., Pavithran, K., Devan, A. R., Pradeep, G. K., Nath, L. R.
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - drug therapy
Drug Evaluation, Preclinical
Humans
Immunoconjugates - therapeutic use
Liver Neoplasms - drug therapy
Medicine
Medicine & Public Health
Oncology
Review Article
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Summary:An antibody–drug conjugate (ADC) is an advanced chemotherapeutic option with immense promises in treating many tumor. They are designed to selectively attack and kill neoplastic cells with minimal toxicity to normal tissues. ADCs are complex engineered immunoconjugates that comprise a monoclonal antibody for site-directed delivery and cytotoxic payload for targeted destruction of malignant cells. Therefore, it enables the reduction of off-target toxicities and enhances the therapeutic index of the drug. Hepatocellular carcinoma (HCC) is a solid tumor that shows high heterogeneity of molecular phenotypes and is considered the second most common cause of cancer-related death. Studies show enormous potential for ADCs targeting GPC3 and CD24 and other tumor-associated antigens in HCC with their high, selective expression and show potential outputs in preclinical evaluations. The review mainly highlights the preclinical evaluation of different antigen-targeted ADCs such as MetFab-DOX, Anti-c-Met IgG-OXA, Anti CD 24, ANC–HN-01, G7mab-DOX, hYP7-DCand hYP7-PC, Anti-CD147 ILs-DOX and AC133-vcMMAF against hepatocellular carcinoma and its future relevance. Graphic abstract
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-021-02707-5