Role of the Cardiophrenic Lymph Node Status After Neoadjuvant Chemotherapy in Primary Advanced Ovarian Cancer

Background/Aim: This study investigated the cardiophrenic lymph node (CPLN) status before and after neoadjuvant chemotherapy (NACT), as its presence seems to have a rather prognostic significance in patients with advanced ovarian cancer. Patients and Methods: The baseline computed tomography scans o...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2021-10, Vol.41 (10), p.5025-5031
Main Authors: LUENGAS-WUERZINGER, VERONICA, RAWERT, FRIEDERIKE, CLAßEN-VON SPEE, SABRINA, BARANSI, SAHER, SCHULER, ESTHER, CARRIZO, KATHARINA, MALLMANN, PETER, LAMPE, BJOERN
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Chemotherapy
Computed tomography
Enlargement
Lymph nodes
Lymphatic system
Ovarian cancer
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aim: This study investigated the cardiophrenic lymph node (CPLN) status before and after neoadjuvant chemotherapy (NACT), as its presence seems to have a rather prognostic significance in patients with advanced ovarian cancer. Patients and Methods: The baseline computed tomography scans of 66 patients with advanced ovarian cancer primary treated with NACT between March 2015 and June 2020 were reviewed. A CPLN enlargement was defined as ≥5 mm. Results: 44% (n=29) of the patients had enlarged CPLNs; 10.7% (n=3) showed a complete response, 71.4% (n=20) a partial response, and 17.9% (n=5) a stable disease after NACT. There was no significant difference between the response to NACT measured according to the status of CPLN compared to other biomarkers in the CPLN group. Conclusion: Patients with CPLN enlargement have a tendency to an impaired prognosis. The response of CPLN to NACT was comparable to the response of established biomarkers, adding a monitoring function to the CPLN.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15317